Non-motor Symptoms and Brain Dopamine Transporter Binding

Active, not recruiting

• Conditions: Parkinsonism; Parkinson Disease
• Interventions: Other: DAT SPECT imaging

• Registration Number: NCT02650843
• Lead Sponsor: Turku University Hospital

Brief Summary

This project aims to clarify the role non-motor symptoms in the development of Parkinson's disease (PD) and to improve diagnostics at very early stages of PD. The project involves multidimensional measures of disease biomarkers together with brain dopamine transporter (DAT) imaging with \[123I\]FP-CIT single photon emission computed tomography (SPECT).

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01
• Study First Submitted: 2016-01-05
• Study First Submitted QC: 2016-01-07
• Study First Posted: 2016-01-08
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-11
• Last Update Posted: 2025-04-13
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 455

Inclusion Criteria

• Male or Female
• Age 18-100 years
• Referred for clinical DAT SPECT in Turku or Helsinki

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with parkinsonism	DAT SPECT imaging	Patients with parkinsonism that are referred for DAT SPECT imaging in Turku University Hospital, Finland or Helsinki University Hospital, Finland

Primary Outcome Measures

Name	Time	Method
DAT SPECT striatal specific binding ratio	Up to 10 years