Are changes in salivary secretion after taking vonoprazan involved in the pathogenesis of refractory gastroesophageal reflux disease? - effect of salivary secretion on GERD

ippon Medical School, Graduate School of Medicine.0 个研究点目标入组 50 人开始时间: 2024年1月9日最近更新: 2024年4月23日

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•1. Take medication that can influence the secretion of saliva, such as antiadrenergic agents and adrenergic alpha-2 agonists, antidepressants, psychotropic drugs, anticholinergic drugs, and smokers in the last two weeks before enrollment. 2. Take medication that affects the secretion of gastric acid, such as PPI, PCAB, and histamine H2 receptor antagonists in the last two weeks before enrollment. 3. Have scleroderma and Sjogren syndrome that can affect esophageal motility and saliva secretion. 4. Have current peptic ulcers. 5. Have an upper gastrointestinal surgery 6. Have severe complications such as heart disease or cancer. 7. Have an allergy to xylocaine. 8. Have an allergy to vonoprazan. 9. pregnant or lactating 10. Have an oral environment in which gum chewing is likely to cause dental problems, such as caries or unstable teeth

发起方

ippon Medical School, Graduate School of Medicine.