Individualized Molecular Profiling for Allocation to Clinical Trials (IMPACT) Project

Recruiting

• Conditions: Solid Tumor

• Registration Number: NCT02806388
• Lead Sponsor: National Cancer Centre, Singapore

Brief Summary

This study aims to screen tumor molecular profile for better selection of anticancer treatment, in particular, allocation to clinical trials if available.

Detailed Description

Molecular profiling will be performed on archival tumor tissue or freshly collected tumor tissue from re-biopsy. Blood, pleural fluid, FNA, and/or saliva may be collected to study the genetic makeup and also to compare the tumor molecular profile. Personalized therapy will be given based on molecular profile.

Study Timeline

• Study Start: 2011-10
• Study First Submitted: 2016-06-16
• Study First Submitted QC: 2016-06-17
• Study First Posted: 2016-06-20
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-20
• Last Update Posted: 2024-03-22
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5500

Inclusion Criteria

• Confirmed histological diagnosis of solid tumor
• Suitable for systematic treatment and clinical trials
• ECOG (Eastern cooperative oncology group) performance status < 2
• Able to provide tumor tissue for molecular profiling
• Able to understand and sign the informed consent form

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The molecular and clinical epidemiology for cancer patients being considered for novel therapeutics	5 years

Secondary Outcome Measures

Name	Time	Method
The correlation of molecular profiles with clinical outcomes	5 years
The proportion of patients who have actionable alterations and enrol into clinical trials	5 years

Trial Locations

Locations (1)

National Cancer Centre, Singapore; 🇸🇬 Singapore, Singapore