Effect of citalopram on chest pain in patients with functional chest pai

Phase 4

Completed

Conditions: 'functional chest pain' and 'chest pain with unkown origin'
10017977

Registration Number: NL-OMON50787

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 54

Inclusion Criteria

* Written informed consent
* Minimum age: 18 years
* Functional chest pain according to Rome IV criteria
* Ruled out cardiac origin of chest pain
* ECG with corrected QT interval (QTc) within the normal range (<450ms male,
<460ms female)
* Symptoms of chest pain for at least 6 months
* Frequency of symptoms at least once a week
* Gastroduodenoscopy, high-resolution manometry and 24-hour pH-impedance
monitoring need to have been performed recently.

Exclusion Criteria

* Currently using antidepressants
* Contraindication for the use of SSRI
* Already tried antidepressants off-label to treat chest pain
* Known allergy to citalopram
* Severe and clinically unstable concomitant disease
* Pregnant, lactating or fertile women (without contraception)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Global assessment of patient reported reduction in chest pain after 6 weeks of<br /><br>treatment.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Global assessment of patient reported reduction in chest pain after 12 weeks of<br /><br>treatment.<br /><br>Symptom severity and frequency<br /><br>Health status and quality of life (SF-36)<br /><br>Psychological comorbidity (HADS)<br /><br>Adverse events/side effects</p><br>