Precision Transcranial Electric Stimulation for the Therapy of Cognitive Impairment

University of Minnesota1 site in 1 country30 target enrollmentSeptember 5, 2022

ConditionsWorking Memory

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Working Memory
Sponsor: University of Minnesota
Enrollment: 30
Locations: 1
Primary Endpoint: Changes in working memory performance
Status: Active, not recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.

Detailed Description

Transcranial alternating current stimulation (tACS) can non-invasively alter neuroelectric activity in the brain by applying weak time-varying electric currents via the scalp. Complex patterns of electric brain activity can take the form of traveling waves - spatially coherent brain rhythms that gradually propagate through the neocortex. Traveling waves are crucial for the temporal coordination of informational flow in the brain. Using the novel traveling-wave transcranial alternating current stimulation (tACS) approach, the investigators will explore the effects of frontal-to-parietal and parietal-to-frontal traveling waves on working memory performance and brain electrophysiology in adults.

Registry

clinicaltrials.gov

Start Date

September 5, 2022

End Date

February 1, 2026

Last Updated

last year

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

University of Minnesota

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age between 18 and 45 years old.
•Confident level of English language.

Exclusion Criteria

•History or evidence of chronic neurological or mental disorder.
•Metal or electric implant in the head, neck, or chest area.
•History of head injuries with loss of consciousness.
•Any acute or chronic medical condition that requires ongoing pharmacological treatment.
•Pregnancy or breast-feeding.
•Alcohol or drug addiction.

Outcomes

Primary Outcomes

Changes in working memory performance

Time Frame: Immediate effect during stimulation

Changes in working memory performance (% of correct responses) as measured with the standardized N-back working memory task during active stimulation relative to pre-stimulation performance.