NCT06507280招募中不适用
The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis
Aydin Adnan Menderes University2 个研究点 分布在 2 个国家目标入组 60 人开始时间: 2024年2月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Caspase-1
研究概览
简要总结
This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.
详细描述
After being informed about the study and potential risks, necessary periodontal measurements will be performed and gingival crevicular fluid will be collected from all patients who gave written informed consent, and patients with gingivitis will be followed up on the 7th and 30th day after periodontal treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 11 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion criteria for the group with gingivitis;
- •Systemically healthy
- •11-14 years old
- •Permanent dentition
- •No need for endodontic and restorative treatment
- •Gingivitis with gingivitis
- •Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study.
- •Inclusion criteria for the healthy group;
- •Systemically healthy
- •11-14 years old
- •Permanent dentition
- •No need for endodontic and restorative treatment
- •Periodontally healthy
- •Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study.
排除标准
- •In need of endodontic and restorative treatment
- •Systemically unhealthy
- •Patients who do not give verbal or written consent
结局指标
主要结局
Caspase-1
时间窗: Baseline
Caspase-1 level
NLRP3
时间窗: Baseline
NOD-, LRR- and pyrin domain-containing protein 3 level
IL-1 Beta
时间窗: Baseline
Interleukin-1 Beta level
次要结局
- Caspase-1(7. days -30. days)
- NLRP3(7. days - 30. days)
- IL-1 Beta(7. days-30. days)
研究者
Sultan KELES
Associate Prof. Dr.
Aydin Adnan Menderes University
研究点 (2)
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