Serum Procalcitonin Study in the Management of Ventilated Patients
Completed
- Conditions
- Ventilator Associated Pneumonia
- Registration Number
- NCT00726167
- Lead Sponsor
- University of Missouri-Columbia
- Brief Summary
The purpose of this study is to test a new method for diagnosing and monitoring Ventilator-Associated Pneumonia, which is a major killer among ICU patients. The method requires analysis of a small amount of the patient's blood for concentration of a hormone called Procalcitonin.
- Detailed Description
Ventilator-associated pneumonia is a leading cause of mortality in critically ill patients. The purpose of this study is to evaluate the relationship between the onset/progress/resolution of pneumonia and the levels of Procalcitonin, a prohormone whose concentrations fluctuate in response to bacterial infection.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 29
Inclusion Criteria
- Are willing to give or who's proxy is willing to consent to be a study subject
- Are at least 18 years of age;
- Who are mechanically ventilated surgical intensive care unit patients.
Exclusion Criteria
- Participation in any investigational device or drug trial within 30 days prior to enrollment.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation of Procalcitonin concentration with the LungGuardian-derived Pneumonia Score in mechanically ventilated surgical intensive care unit patients. Using the data collected a positive and negative predictive value will be calculated. Once daily
- Secondary Outcome Measures
Name Time Method microbiology data Once daily PCT levels Once daily antibiotic status (appropriateness, effectiveness, discontinuation criteria) Once daily intubation date Once daily pneumonia-related symptoms (including tracheal secretion character, body temperature, oxygenation, and WBC counts) Once daily
Trial Locations
- Locations (1)
University of Missouri
🇺🇸Columbia, Missouri, United States