Comparison of the Effect of Various External Pressure on Blood During Rapid Infusion
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Hemolysis and alteration of deformability of red blood cell caused by external pressure
Study Overview
Brief Summary
Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used. The investigators will study correlation between external pressure and hemolysis and deformability of red blood cell.
Detailed Description
Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used which cause hemolysis and alteration of red blood cell. The investigators will study correlation between variable external pressure and hemolysis and deformability of red blood cell. Differ from previous study, the investigator will use scanning electron microscope for observation red blood cell.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 20 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy volunteers, without any underlying disease.
Exclusion Criteria
- •history of delivery, abortion in past 6 months.
- •weight : male under 50kg, female under 45kg
- •heart rate under 50 or over 100
- •fever : over 37.5
- •blood pressure : over 180/100
Arms & Interventions
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control) (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control) (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Intervention: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg (Device)
Outcomes
Primary Outcomes
Hemolysis and alteration of deformability of red blood cell caused by external pressure
Time Frame: 1hour
Secondary Outcomes
No secondary outcomes reported
Investigators
Hyub Huh
M.D.
Korea University Anam Hospital