Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%

Phase 3

Completed

• Conditions: Heart Failure
• Interventions: Drug: Finerenone (BAY94-8862); Other: Placebo

• Registration Number: NCT04435626
• Lead Sponsor: Bayer

Brief Summary

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 6000 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-15
• Study First Submitted QC: 2020-06-15
• Study First Posted: 2020-06-17
• Study Start: 2020-09-14
• Primary Completion: 2024-05-15
• Status Verified: 2024-06
• Study Completion: 2024-06-14
• Last Update Submitted: 2024-07-01
• Last Update Posted: 2024-07-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6016

Inclusion Criteria

• Participant (male or female) must be aged 40 years and older.

• Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.

• On diuretic treatment for at least 30 days prior to randomization.

• Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.

• Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) >30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm

• n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:

  • Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
  • Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.

• Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.

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Exclusion Criteria

• Estimated glomerular filtration rate (eGFR) <25 mL/min/1.73 m² at either screening or randomization visit.
• Serum/plasma potassium >5.0 mmol/L at either screening or randomization visit.
• Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
• Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
• Coronary artery bypass graft surgery in the 90 days prior to randomization
• Percutaneous coronary intervention in the 30 days prior to randomization
• Stroke or transient ischemic cerebral attack within 90 days prior to randomization
• Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin <10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) >50 kg/m2 at screening
• Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
• Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm 1_BAY94-8862	Finerenone (BAY94-8862)	Adult patients receive BAY94-8862
Arm 2_Placebo	Placebo	Adult patients receive placebo

Primary Outcome Measures

Name	Time	Method
Number of cardiovascular deaths and heart failure events	Up to 42 months	Composite endpoint. Heart Failure events comprise first and recurrent events

Secondary Outcome Measures

Name	Time	Method
Time to death from any cause	Up to 42 months
Improvement in NYHA class from Baseline to Month 12	Up to 12 month after start of treatment
Time to first occurrence of composite renal endpoint	Up to 42 months	Composite renal endpoint: sustained decrease in estimated glomerular filtration rate (eGFR) ≥50% relative to baseline over at least 4 weeks, or sustained eGFR decline to \<15ml/min/1.73m2 or initiation of dialysis or renal transplantation.
Change in Total Symptom Score (TSS) from KCCQ.	At baseline, Months 6, 9 and 12	Patient Reported Outcomes measured by Kansas City Cardiomyopathy Questionnaire (KCCQ)
Time to total (first and recurrent) HF events	Up to 42 months

Trial Locations

Locations (657)

Eastern Shore Research Institute, LLC | Fairhope, AL; 🇺🇸 Fairhope, Alabama, United States

Mobile Heart Specialists, PC; 🇺🇸 Mobile, Alabama, United States

Heart Clinic Arkansas; 🇺🇸 Little Rock, Arkansas, United States

University of Arizona Health Science Center; 🇺🇸 Tucson, Arizona, United States

National Heart Institute; 🇺🇸 Beverly Hills, California, United States

UC Irvine Medical Center; 🇺🇸 Orange, California, United States

California Heart Specialists; 🇺🇸 Cypress, California, United States

NorthBay Clinical Research, LLC | Santa Rosa, CA; 🇺🇸 Santa Rosa, California, United States

Harbor - UCLA Medical Center; 🇺🇸 Torrance, California, United States

Blue Coast Research Center, LLC; 🇺🇸 Vista, California, United States

Interventional Cardio Medical- DCT Department; 🇺🇸 West Hills, California, United States

Interventional Cardiology Medical Group | West Hills, CA; 🇺🇸 West Hills, California, United States

Colorado Springs Cardiology; 🇺🇸 Colorado Springs, Colorado, United States

South Denver Cardiology Associates, PC; 🇺🇸 Littleton, Colorado, United States

Cardiology Associates Research Company; 🇺🇸 Daytona Beach, Florida, United States

Southwest Florida Research | Naples, FL; 🇺🇸 Naples, Florida, United States

East Coast Institute for Research | St. Augustine, FL; 🇺🇸 Saint Augustine, Florida, United States

Cardiology Partners; 🇺🇸 Wellington, Florida, United States

IACT Health; 🇺🇸 Columbus, Georgia, United States

Edward Hospital-Main Campus; 🇺🇸 Naperville, Illinois, United States

Captain James A. Lovell Federal Health Care Center; 🇺🇸 North Chicago, Illinois, United States

Louisiana Heart Center Research - Slidell; 🇺🇸 Slidell, Louisiana, United States

Aa Mrc, Llc; 🇺🇸 Flint, Michigan, United States

Advanced Heart Care, LLC | Bridgewater, NJ; 🇺🇸 Bridgewater, New Jersey, United States

Saratoga Clinical Research, LLC; 🇺🇸 Saratoga Springs, New York, United States

Northwell Health Phys. Partners Cardiology at Valley Stream; 🇺🇸 Valley Stream, New York, United States

Capital Area Research, LLC; 🇺🇸 Camp Hill, Pennsylvania, United States

Kent Hospital; 🇺🇸 Warwick, Rhode Island, United States

Lt. Col. Luke Weathers, Jr. VA Medical Center; 🇺🇸 Memphis, Tennessee, United States

Texas Health Physicians Group - Fort Worth; 🇺🇸 Fort Worth, Texas, United States

Houston Heart & Vascular Associates; 🇺🇸 Humble, Texas, United States

North Dallas Research Associate | McKinney, TX; 🇺🇸 McKinney, Texas, United States

Sentara Norfolk General Hospital; 🇺🇸 Norfolk, Virginia, United States

Hospital Militar Central "CIR. MY. C. Argerich"; 🇦🇷 Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina

John Hunter Hospital; 🇦🇺 New Lambton Heights, New South Wales, Australia

The Prince Charles Hospital; 🇦🇺 Chermside, Australia

Klinikum Klagenfurt am Wörthersee; 🇦🇹 Klagenfurt, Kärnten, Austria

Landeskrankenhaus Feldkirch; 🇦🇹 Feldkirch, Vorarlberg, Austria

Imed19-privat; 🇦🇹 Wien, Austria

Fundação Universidade de Caxias do Sul; 🇧🇷 Caxias do Sul, Rio Grande Do Sul, Brazil

Hospital Mae de Deus; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Hospital Felício Rocho; 🇧🇷 Belo Horizonte, Sao Paulo, Brazil

Eurolatino Pesquisas Medicas | Uberlandia, MG; 🇧🇷 Minas Gerais, Brazil

Ambulatory facility for specialized outpatient medical care; 🇧🇬 Burgas, Bulgaria

Brampton Clinical Trials; 🇨🇦 Brampton, Ontario, Canada

Beijing Friendship Hospital, Capital Medical University; 🇨🇳 Beijing, China

Caja de Compensación Familiar CAFAM; 🇨🇴 Bogota, Distrito Capital De Bogotá, Colombia

Clínica Imbanaco S.A.S; 🇨🇴 Cali, Valle Del Cauca, Colombia

Städt. Kliniken Bielefeld gGmbH; 🇩🇪 Bielefeld, Nordrhein-Westfalen, Germany

A.O.U. di Bologna Policlinico S.Orsola Malpighi; 🇮🇹 Bologna, Emilia-Romagna, Italy

A.O.U. Maggiore della Carità; 🇮🇹 Novara, Piemonte, Italy

Cardiovascular & Vein Center of Florida | Bradenton, FL; 🇺🇸 Bradenton, Florida, United States

Nova Clinical Research | Brandenton, FL; 🇺🇸 Bradenton, Florida, United States

Atlanta Heart Specialists, LLC; 🇺🇸 Tucker, Georgia, United States

Advocate Illinois Masonic Medical Center; 🇺🇸 Chicago, Illinois, United States

Maryland Cardiovascular Specialists; 🇺🇸 Baltimore, Maryland, United States

John Hopkins Outpatient Center; 🇺🇸 Baltimore, Maryland, United States

Western Michigan University School of Medicine; 🇺🇸 Kalamazoo, Michigan, United States

St. Cloud Hospital; 🇺🇸 Saint Cloud, Minnesota, United States

Southwest Family Medicine Associates; 🇺🇸 Dallas, Texas, United States

University of Texas Medical Branch at Galveston; 🇺🇸 Galveston, Texas, United States

South Texas Cardiovascular Consultants, PLLC / Kerrville, TX; 🇺🇸 Kerrville, Texas, United States

Northwest Houston Heart Center; 🇺🇸 Tomball, Texas, United States

G.A. Research Associates, Ltd.; 🇨🇦 Moncton, New Brunswick, Canada

Deenanath Mangeshkar Hospital; 🇮🇳 Pune, Maharashtra, India

A.O.U. Policlinico Federico II Napoli; 🇮🇹 Napoli, Campania, Italy

Hospital Central de Asturias; 🇪🇸 Oviedo, Asturias, Spain

NZOZ Pro-Cordis Sopockie Centrum Badan Kardiologicznych; 🇵🇱 Sopot, Poland

Isala Meppel; 🇳🇱 Meppel, Netherlands

University of Auckland; 🇳🇿 Auckland, New Zealand

Dunedin Hospital; 🇳🇿 Dunedin, New Zealand

Nelson Hospital; 🇳🇿 Nelson, New Zealand

Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn; 🇵🇱 Krakow, Poland

Centro Hospitalar Universitario Cova de Beira | Clinical Research Department; 🇵🇹 Covilha, Castelo Branco, Portugal

Centro Hospitalar Universitario do Porto; 🇵🇹 Porto, Portugal

S.C Thera Card S.R.L; 🇷🇴 Brasov, Romania

Emergency Clinical County Hospital Craiova; 🇷🇴 Craiova Dolj, Romania

Kazan Federal University; 🇷🇺 Kazan, Russian Federation

Hospital Universitario Arnau de Vilanova de Lleida; 🇪🇸 Lleida, Spain

Hospital Universitario 12 de Octubre; 🇪🇸 Madrid, Spain

Trakya Univ. Tip Fak.; 🇹🇷 Edirne, Turkey

Women's College Hospital; 🇨🇦 Toronto, Ontario, Canada

LifeSpring Research Foundation, LLC; 🇺🇸 Miami, Florida, United States

M Health Fairview Heart Clinic - Fulton; 🇺🇸 Minneapolis, Minnesota, United States

Clinical Advancement Center, PLLC; 🇺🇸 San Antonio, Texas, United States

Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ.; 🇨🇳 Guangzhou, Guangdong, China

Nanfang Hospital, Southern Medical University; 🇨🇳 Guangzhou, Guangdong, China

Hainan Provincial People's Hospital; 🇨🇳 Haikou, Hainan, China

The First People's Hospital of Lianyungang; 🇨🇳 Lianyungang, Jiangsu, China

Hainan Third People's Hospital (Province Nongken Sanya Hopt); 🇨🇳 Sanya, Hainan, China

NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School; 🇨🇳 Nanjing, Jiangsu, China

Jilin Province People's Hospital; 🇨🇳 Changchun, Jilin, China

Panjin Liaohe Oilfield Gem Flower Hospital; 🇨🇳 Panjin, Liaoning, China

General Hospital of Ningxia Medical University; 🇨🇳 Yinchuan, Ningxia, China

Jinan Central Hospital; 🇨🇳 Jinan, Shandong, China

Shanxi Provincial People's Hospital; 🇨🇳 XI 'an, Shanxi, China

1st Affiliated Hospital of College Medicine, Zhejiang Univ.; 🇨🇳 Hangzhou, Zhejiang, China

Beijing Anzhen Hospital, Capital Medical University; 🇨🇳 Beijing, China

Hospital do Coração do Brasil; 🇧🇷 Brasilia, Distrito Federal, Brazil

Santa Casa de Misericórdia da Bahia; 🇧🇷 Salvador, Bahia, Brazil

A.O. di Perugia; 🇮🇹 Perugia, Umbria, Italy

Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

St. Boniface Hospital; 🇨🇦 Winnipeg, Manitoba, Canada

University of Utah Health Care; 🇺🇸 Salt Lake City, Utah, United States

Hospital Italiano de La Plata | Clinical Research Department; 🇦🇷 La Plata, Buenos Aires, Argentina

Tolna Varmegyei Balassa Janos Korhaz; 🇭🇺 Szekszard, Hungary

Universitätsklinikum AKH Wien; 🇦🇹 Wien, Austria

Multiprofile Hospital for Active Treatment Medline | Cardiology Department; 🇧🇬 Plovdiv, Bulgaria

Da Vinci Maganklinika; 🇭🇺 Pecs, Hungary

Onga Nakama Medical Association Onga Hospital; 🇯🇵 Onga-gun, Fukuoka, Japan

Hyogo Brain and Heart Center; 🇯🇵 Himeji, Hyogo, Japan

National Hospital Organization Shinshu Ueda Medical Center; 🇯🇵 Ueda, Nagano, Japan

Universitair Medisch Centrum Groningen; 🇳🇱 Groningen, Netherlands

Baptist Heart -Cardiology - DCT Dept; 🇺🇸 Jackson, Mississippi, United States

Advara HeartCare Ringwood; 🇦🇺 Bundoora, Victoria, Australia

Corporación Médica de General San Martín; 🇦🇷 San Martín, Buenos Aires, Argentina

Universitätsklinikum St. Pölten; 🇦🇹 St. Pölten, Niederösterreich, Austria

Mercy Hospital Springfield; 🇺🇸 Springfield, Missouri, United States

Cardiovascular Research of Knoxville; 🇺🇸 Powell, Tennessee, United States

Centro de Investigaciones Clínicas; 🇦🇷 Caba, Ciudad Auton. De Buenos Aires, Argentina

Instituto de Cardiologia | Tucuman, AR; 🇦🇷 San Miguel de Tucuman, Tucuman, Argentina

Hospital Universitario Clínica San Rafael; 🇨🇴 Bogota, Colombia

Instituto Cardiovascular de Buenos Aires - Buenos Aires, Argentina; 🇦🇷 Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina

The Stern Cardiovascular Foundation, Inc.; 🇺🇸 Germantown, Tennessee, United States

Maine Medical Partners-Maine Health Cardiology; 🇺🇸 Scarborough, Maine, United States

MK Consultoria Médico Científica Ltda/Angiocor Blumenau; 🇧🇷 Blumenau, Santa Catarina, Brazil

Sanford USD Medical Center; 🇺🇸 Sioux Falls, South Dakota, United States

TOYOTA Memorial Hospital; 🇯🇵 Toyota, Aichi, Japan

Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office; 🇯🇵 Hakusan, Ishikawa, Japan

Japan Red Cross Society Azumino Hospital; 🇯🇵 Azumino, Nagano, Japan

Fukuoka University Nishijin Hospital; 🇯🇵 Fukuoka, Japan

Osaka General Medical Center; 🇯🇵 Osaka, Japan

Hospital Pulau Pinang; 🇲🇾 Pulau Pinang, Malaysia

KLIMED Marek Klimkiewicz; 🇵🇱 Bialystok, Poland

IMEDICA Centrum Medyczne; 🇵🇱 Lublin, Poland

Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o.; 🇵🇱 Oswiecim, Poland

Twoja Przychodnia - Szczecinskie Centrum Medyczne; 🇵🇱 Szczecin, Poland

S.C. CARDIOMED S.R.L. Iasi; 🇷🇴 Iasi, Romania

G. GENNIMATAS General State Hospital of Athens; 🇬🇷 Athens, Greece

Rambam Health Corporation; 🇮🇱 Haifa, Israel

National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office; 🇯🇵 Kanazawa, Ishikawa, Japan

Kitasato University Hospital; 🇯🇵 Sagamihara, Kanagawa, Japan

Ageo Central General Hospital; 🇯🇵 Ageo, Saitama, Japan

Saitama Sekishinkai Hospital; 🇯🇵 Sayama, Saitama, Japan

The Sakakibara Heart Institute of Okayama; 🇯🇵 Okayama, Japan

Toyama University Hospital; 🇯🇵 Toyama, Japan

Saules family medicine center; 🇱🇹 Kaunas, Lithuania

Maastricht UMC; 🇳🇱 Maastricht, Netherlands

Funabashi Municipal Medical Center; 🇯🇵 Funabashi, Chiba, Japan

Kagawa Prefectural Central Hospital; 🇯🇵 Takamatsu, Kagawa, Japan

R.I.A.C Naha City Hospital; 🇯🇵 Naha, Okinawa, Japan

Kishiwada Tokushukai Hospital; 🇯🇵 Kishiwada, Osaka, Japan

National Hospital Organization Kumamoto Medical Center; 🇯🇵 Kumamoto, Japan

Oita Prefectural Hospital; 🇯🇵 Oita, Japan

Gleneagles Penang Medical Center; 🇲🇾 George Town,, Malaysia

Hospital Serdang; 🇲🇾 Selangor, Malaysia

Centro de Estudios Clinicos de Queretaro S. C. (CECLIQ); 🇲🇽 Queretaro, Querétaro, Mexico

Centro de Investigacion y Atencion Integral Durango S.C.; 🇲🇽 Durango, Mexico

Tergooiziekenhuizen-Blaricum; 🇳🇱 Blaricum, Netherlands

Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center; 🇵🇹 Leiria, Portugal

Izhevsk City Clinical Hospital #9; 🇷🇺 Izhevsk, Russian Federation

Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto; 🇸🇰 Bratislava, Slovakia

KardioMed s.r.o.; 🇸🇰 Lucenec, Slovakia

ULSM - Hospital Pedro Hispano; 🇵🇹 Matosinhos, Porto, Portugal

Shobara Red Cross Hospital; 🇯🇵 Shobara, Hiroshima, Japan

Toho University Omori Medical Center; 🇯🇵 Ota-ku, Tokyo, Japan

Kumamoto University Hospital; 🇯🇵 Kumamoto, Japan

Hospital Raja Permaisuri Bainun; 🇲🇾 Perak, Malaysia

Sarawak Heart Centre; 🇲🇾 Sarawak, Malaysia

Ziekenhuis Gelderse Vallei; 🇳🇱 Ede, Netherlands

Catharina Ziekenhuis; 🇳🇱 Eindhoven, Netherlands

NZOZ "Twoja Przychodnia" Sp. z o.o.; 🇵🇱 Lublin, Poland

Szpital Specjalistyczny SPZOZ; 🇵🇱 Pulawy, Poland

Emergency Institute for Cardiovascular Diseases; 🇷🇴 Bucuresti, Romania

Spitalul Clinic de Urgenta "Sf. Pantelimon"; 🇷🇴 Bucuresti, Romania

S.C. Sal Med SRL; 🇷🇴 Pitesti, Romania

Omsk Region "Clinical Health Unit No. 9"; 🇷🇺 Omsk, Russian Federation

Regional Dispensary of Radiation Protection of Population; 🇺🇦 Kharkiv, Ukraine

University Hospitals Leicester; 🇬🇧 Leicester, Leicestershire, United Kingdom

National Hospital Organization Tokyo Medical Center; 🇯🇵 Meguro-ku, Tokyo, Japan

Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial; 🇪🇸 Ferrol, A Coruña, Spain

Hospital da Luz - Setubal; 🇵🇹 Setubal, Setúbal, Portugal

Centro de Investigación Médica Dr. Alberto Bazzoni SA de CV; 🇲🇽 Torreón, Coahuila, Mexico

Fundación de Atencion e Investigacion Medica Lindavista SC; 🇲🇽 Alcaldia Gustavo A. Madero, Distrito Federal, Mexico

Hospital Ángeles de Xalapa; 🇲🇽 Xalapa, Veracruz, Mexico

Centro Hospitalar de Lisboa Ocidental | Clin Res Dept; 🇵🇹 Lisboa, Portugal

Emergency County Hospital, Braila; 🇷🇴 Braila, Romania

Sf. Ap. Andrei Emergency Clinical County Hospital Galati; 🇷🇴 Galati, Romania

Hospital del Servei Valencià de Salud de la Vega Baja; 🇪🇸 San Bartolomé, Alicante, Spain

City Clinical Hospital #51; 🇷🇺 Moscow, Russian Federation

Maxima Medisch Centrum, locatie Veldhoven; 🇳🇱 Veldhoven, Netherlands

Zechowicz Medeusz-Plus Lekarska Spolka Partnerska; 🇵🇱 Olsztyn, Poland

Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research Unit; 🇵🇹 Coimbra, Portugal

CMI. Dr. Podoleanu Cristian; 🇷🇴 Targu Mures, Mures, Romania

Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare; 🇷🇴 Baia Mare, Romania

SBHI of Sverdlovsk Region Aramil City Hospital; 🇷🇺 Aramil, Russian Federation

Stredoslovensky ustav srdcovych a cievnych chorob, a.s.; 🇸🇰 Banska Bystrica, Slovakia

MEDI M&M, s.r.o.; 🇸🇰 Moldava nad Bodvou, Slovakia

Medivasa s.r.o.; 🇸🇰 Zilina, Slovakia

Regional Clinical Hospital - Vinnytsya; 🇺🇦 Vinnytsya, Ukraine

Narodny ustav srdcovych a cievnych chorob, a.s; 🇸🇰 Bratislava 37, Slovakia

Nemocnica svateho Michala, a.s.; 🇸🇰 Bratislava, Slovakia

Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho; 🇸🇰 Dolny Kubin, Slovakia

JG-COR s.r.o.; 🇸🇰 Kosice, Slovakia

KARDIOMED NZ s.r.o.; 🇸🇰 Nove Zamky, Slovakia

COR, s.r.o; 🇸🇰 Sahy, Slovakia

Royal Bournemouth General Hospital; 🇬🇧 Bournemouth, Dorset, United Kingdom

Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine Department; 🇪🇸 Sanlucar de Barrameda, Cádiz, Spain

Hospital Universitario Virgen de la Victoria | Cardiology Department; 🇪🇸 Malaga, Málaga, Spain

Chang Gung Memorial Hospital at Linkou; 🇨🇳 Tao-Yuan, Taiwan

Miska Klinichna likarnya No 8; 🇺🇦 Kharkiv, Ukraine

Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi; 🇺🇦 Poltava, Ukraine

Wansbeck General Hospital; 🇬🇧 Ashington, Northumberland, United Kingdom

Blackpool Victoria Hospital; 🇬🇧 Blackpool, Lancashire, United Kingdom

Hospital Dr. Negrín; 🇪🇸 Las Palmas de Gran Canaria, Las Palmas, Spain

Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine Department; 🇪🇸 Villamartin, Cádiz, Spain

Institute of Cardiology AMS; 🇺🇦 Kiev, Ukraine

Zaporizhia Municipal Clinical Hospital No.10; 🇺🇦 Zaporizhzhya, Ukraine

North Hampshire Hospital; 🇬🇧 Basingstoke, Hampshire, United Kingdom

Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research; 🇩🇰 Herning, Denmark

Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit; 🇩🇰 Svendborg, Denmark

Cardiology, PC; 🇺🇸 Birmingham, Alabama, United States

Henry Ford Health System; 🇺🇸 Detroit, Michigan, United States

South Oklahoma Heart Research, LLC; 🇺🇸 Oklahoma City, Oklahoma, United States

VA Eastern Colorado Health Care System; 🇺🇸 Aurora, Colorado, United States

Suburban Hospital; 🇺🇸 Bethesda, Maryland, United States

Aurora Saint Luke's Medical Center; 🇺🇸 Milwaukee, Wisconsin, United States

Yinchuan No.1 People's Hospital; 🇨🇳 Yinchuan, Ningxia, China

Pusan National University Hospital; 🇰🇷 Busan, Korea, Republic of

Advocate Good Samaritan Hospital; 🇺🇸 Downers Grove, Illinois, United States

Methodist Medical Center of Illinois; 🇺🇸 Peoria, Illinois, United States

Kansas Nephrology Research Institute, LLC; 🇺🇸 Wichita, Kansas, United States

Cardiovascular Associates Research, LLC; 🇺🇸 Covington, Louisiana, United States

Southern Clinical Research, LLC; 🇺🇸 Zachary, Louisiana, United States

Heart Clinic of Hammond; 🇺🇸 Hammond, Louisiana, United States

Cardiovascular Specialists of Central Maryland, PA; 🇺🇸 Baltimore, Maryland, United States

M Health Fairview; 🇺🇸 Maplewood, Minnesota, United States

University of Mississippi Medical Center; 🇺🇸 Jackson, Mississippi, United States

Harry S. Truman Memorial Veterans Hospital; 🇺🇸 Columbia, Missouri, United States

Logan Health Research; 🇺🇸 Kalispell, Montana, United States

CHI Health Clinic Heart Institute - Grand Island; 🇺🇸 Grand Island, Nebraska, United States

CHI Health Nebraska Heart; 🇺🇸 Lincoln, Nebraska, United States

NJ Heart | Linden, NJ; 🇺🇸 Linden, New Jersey, United States

Garden State Heart Care; 🇺🇸 Manalapan, New Jersey, United States

Hudson Valley Cardiovascular Practice, PC; 🇺🇸 Poughkeepsie, New York, United States

Stony Brook University Medical Center; 🇺🇸 Stony Brook, New York, United States

Laurelton Heart Specialists; 🇺🇸 Rosedale, New York, United States

Mercy Health - St. Elizabeth Youngstown Hospital; 🇺🇸 Youngstown, Ohio, United States

Doylestown Cardiology Associates-VIAA; 🇺🇸 Doylestown, Pennsylvania, United States

Kettering Health Network; 🇺🇸 Kettering, Ohio, United States

Rama Research LLC | Marion, OH; 🇺🇸 Marion, Ohio, United States

Trident Cardiology Associates, PA; 🇺🇸 Ladson, South Carolina, United States

Carolina Heart Specialists | Lancaster; 🇺🇸 Lancaster, South Carolina, United States

PMG Research of Charleston; 🇺🇸 Mount Pleasant, South Carolina, United States

Monument Health Clinical Research; 🇺🇸 Rapid City, South Dakota, United States

Apex Cardiology, LLC; 🇺🇸 Jackson, Tennessee, United States

Texas Health Physicians Group - Dallas; 🇺🇸 Dallas, Texas, United States

ClinRx Research, LLC; 🇺🇸 Plano, Texas, United States

South Texas Cardiovascular Consultants, PLLC; 🇺🇸 San Antonio, Texas, United States

Virginia Heart; 🇺🇸 Leesburg, Virginia, United States

IMG Cardiology- Fairfax; 🇺🇸 Fairfax, Virginia, United States

Salem VA Medical Center; 🇺🇸 Salem, Virginia, United States

IMOBA Investigaciones Clinicas; 🇦🇷 Caba, Buenos Aires, Argentina

Clínica Coronel Suarez; 🇦🇷 Coronel Suarez, Buenos Aires, Argentina

Aspirus Research Institute; 🇺🇸 Wausau, Wisconsin, United States

Selma Medical Associates; 🇺🇸 Winchester, Virginia, United States

Centro de Investigaciones Medicas Lanus | Research Department; 🇦🇷 Lanus, Buenos Aires, Argentina

Sanatorio Modelo Quilmes; 🇦🇷 Quilmes, Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Zárate; 🇦🇷 Zárate, Buenos Aires, Argentina

Centro de Investigaciones Metabólicas; 🇦🇷 Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina

Centro de Especialidades Medicas (Cemedic) | Cardiology Department; 🇦🇷 Villa Luro, Ciudad Auton. De Buenos Aires, Argentina

Instituto Cardiovascular; 🇦🇷 Rosario, Santa Fe, Argentina

Inst. de Cardiología de Corrientes Juana Francisca Cabral; 🇦🇷 Corrientes, Argentina

Clínica Privada del Prado; 🇦🇷 Córdoba, Argentina

Instituto Médico DAMIC- Fundación Rusculleda; 🇦🇷 Córdoba, Argentina

Centro de Investigaciones Clinicas del Litoral; 🇦🇷 Santa Fe, Argentina

The Wesley Hospital; 🇦🇺 Auchenflower, Queensland, Australia

Royal Brisbane and Women's Hospital; 🇦🇺 Herston, Queensland, Australia

Advara HeartCare Leabrook; 🇦🇺 Leabrook, South Australia, Australia

Medizinische Universität Graz; 🇦🇹 Graz, Steiermark, Austria

Krankenhaus St. Josef Braunau; 🇦🇹 Braunau, Oberösterreich, Austria

Uniklinikum Salzburg - Landeskrankenhaus; 🇦🇹 Salzburg, Austria

Klinik Floridsdorf - Krankenhaus Nord; 🇦🇹 Wien, Austria

Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia; 🇧🇷 Goiânia, Goiás, Brazil

Quanta Diagnostico Por Imagem | Research and Innovation Department; 🇧🇷 Curitiba, Parana, Brazil

Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa; 🇧🇷 Paraná, Parana, Brazil

Instituto do Coração de Marilia | Marilia, Brasil; 🇧🇷 Marília, Sao Paulo, Brazil

Centro Avançado de Pesquisa para Diagnóstico - CAPED; 🇧🇷 Ribeirão Preto, Sao Paulo, Brazil

IMC - Instituto de Moléstias Cardiovasculares Tatui; 🇧🇷 Tatui, Sao Paulo, Brazil

Centro de Pesquisa Clinica do Coração | Aracaju, Brasil; 🇧🇷 Aracaju, Sergipe, Brazil

Santa Casa de Misericórdia de Votuporanga; 🇧🇷 Votuporanga, Sao Paulo, Brazil

Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas; 🇧🇷 Campinas, Brazil

MHAT Haskovo; 🇧🇬 Haskovo, Bulgaria

MHAT Zdrave; 🇧🇬 Pazardjik, Bulgaria

¿ultidisc. hosp. for act. treatm. Sveti Georgi - Pernik OOD; 🇧🇬 Pernik, Bulgaria

Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department; 🇧🇬 Plovdiv, Bulgaria

Medical Center Medconsult Pleven; 🇧🇬 Pleven, Bulgaria

Medical centre Hipokrat - N EOOD; 🇧🇬 Plovdiv, Bulgaria

Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine; 🇧🇬 Shumen, Bulgaria

MHAT Hadzhi Dimitar; 🇧🇬 Sliven, Bulgaria

Second Medical Center Sofia EOOD; 🇧🇬 Sofia, Bulgaria

MHAT National Cardiology Hospital EAD; 🇧🇬 Sofia, Bulgaria

Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department; 🇧🇬 Sofia, Bulgaria

Medical Center Hera; 🇧🇬 Sofia, Bulgaria

NMTH Tzar Boris III; 🇧🇬 Sofia, Bulgaria

Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department; 🇧🇬 Sofia, Bulgaria

UMHAT Tsaritsa Joanna-ISUL EAD Sofia; 🇧🇬 Sofia, Bulgaria

MHAT Trakia; 🇧🇬 Stara Zagora, Bulgaria

Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department; 🇧🇬 Veliko Tarnovo, Bulgaria

Multiprofile Hospital for Active Treatment Sveti Panteleymon Yambol | Cardiology Department; 🇧🇬 Yambol, Bulgaria

Fraser Clinical Trials, Inc.; 🇨🇦 New Westminster, British Columbia, Canada

Cambridge Cardiac Care Center; 🇨🇦 Cambridge, Ontario, Canada

London Health Sciences Centre; 🇨🇦 London, Ontario, Canada

Vizel Cardiac Research; 🇨🇦 Cambridge, Ontario, Canada

North York Diagnostic and Cardiac Centre; 🇨🇦 North York, Ontario, Canada

KMH Cardiology Clinics Inc.; 🇨🇦 Mississauga, Ontario, Canada

Office of Dr. James Cha, MD; 🇨🇦 Oshawa, Ontario, Canada

Oakville Cardiovascular Research; 🇨🇦 Oakville, Ontario, Canada

Kawartha Cardiology Clinical Trials; 🇨🇦 Peterborough, Ontario, Canada

Medicus MFC Inc.; 🇨🇦 Toronto, Ontario, Canada

Corcare; 🇨🇦 Scarborough, Ontario, Canada

Centre intégré de santé et de services sociaux de Laval, Hôp; 🇨🇦 Laval, Quebec, Canada

Mount Sinai Hospital; 🇨🇦 Toronto, Ontario, Canada

Clinique Sante Cardio MC; 🇨🇦 Montreal, Quebec, Canada

Centre Hospitalier de l'Université de Montréal-CHUM; 🇨🇦 Montreal, Quebec, Canada

Montreal General Hospital; 🇨🇦 Montreal, Quebec, Canada

Fujian Provincial Hospital; 🇨🇳 Fuzhou, Fujian, China

Lanzhou University Second Hospital; 🇨🇳 Lanzhou, Gansu, China

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China

The First Affiliated Hospital of Sun Yat-Sen University; 🇨🇳 Guangzhou, Guangdong, China

The First Affiliated Hospital of Guangzhou University of TCM; 🇨🇳 Guangzhou, Guangdong, China

Guizhou Provincial People's Hospital; 🇨🇳 Guiyang, Guizhou, China

The First Affiliated Hospital of Jinan University; 🇨🇳 Guangzhou, Guangdong, China

Xinxiang Central Hospital; 🇨🇳 Xinxiang, Henan, China

Daqing Oilfield General Hospital; 🇨🇳 Daqing, Heilongjiang, China

The First Hospital of Hebei Medical Univesity; 🇨🇳 Shijiazhuang, Hebei, China

Hunan Provincial People's Hospital; 🇨🇳 Changsha, Hunan, China

Changsha Central Hospital; 🇨🇳 Changsha, Hunan, China

The Third Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China

Huai'an First People's Hospital, Nanjing Medical University; 🇨🇳 Huai'An, Jiangsu, China

The Second Affiliated Hospital of Nanjing Medical university; 🇨🇳 Nanjing, Jiangsu, China

Zhongda Hospital Southeast University; 🇨🇳 Nanjing, Jiangsu, China

Nanjing Jiangning Hospital; 🇨🇳 Nanjing, Jiangsu, China

Jiangsu Province Hospital; 🇨🇳 Nanjing, Jiangsu, China

1st Affiliated hospital of Soochow University; 🇨🇳 Suzhou, Jiangsu, China

The First Hospital of Jilin University; 🇨🇳 Changchun, Jilin, China

The First Affiliated Hospital of Xi'an Jiaotong University; 🇨🇳 Xi'an, Shanxi, China

SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos; 🇨🇳 Chengdu, Sichuan, China

Shaanxi Provincial People's Hospital; 🇨🇳 Xi'an, Shanxi, China

West China Hospital Sichuan University; 🇨🇳 Chengdu, Sichuan, China

People's Hospital of Xinjiang Uygur Autonomous Region; 🇨🇳 Urumqi, Xinjiang, China

The First Affiliated Hospital of Xinjiang Medical University; 🇨🇳 Urumqi, Xinjiang, China

Tianjin People's Hospital; 🇨🇳 Tianjin, China

Hospital Alma Mater de Antioquia; 🇨🇴 Medellín, Antioquia, Colombia

Beijing Tsinghua Changgung Hospital; 🇨🇳 Beijing, China

Shanghai Tongji Hospital of Tongji University; 🇨🇳 Shanghai, China

Hospital General de Medellin; 🇨🇴 Medellin, Antioquia, Colombia

Shanghai East Hospital Affiated to Tongji University; 🇨🇳 Shanghai, China

Rodrigo Botero S.A.S; 🇨🇴 Medellin, Antioquia, Colombia

Sociedad Médica Rionegro SOMER S.A.; 🇨🇴 Rionegro, Antioquia, Colombia

IPS Centro Cientifico Asistencial S.A.S; 🇨🇴 Barranquilla, Atlántico, Colombia

Clínica de la Costa SAS; 🇨🇴 Baranquilla, Atlántico, Colombia

Clinica Cardio VID; 🇨🇴 Medellin, Colombia

Corazón IPS S.A.S.; 🇨🇴 Barranquilla, Atlántico, Colombia

Fundacio del Caribe para la Investigacio Bio-Medica (BIOS); 🇨🇴 Barranquilla, Colombia

Hospital San Vicente Fundación; 🇨🇴 Medellin, Colombia

Mediservis del Tolima IPS S.A.S; 🇨🇴 Ibague, Tolima, Colombia

Instituto del Corazón de Bucaramanga; 🇨🇴 Bucaramanga, Santander, Colombia

Fundación Cardioinfantil; 🇨🇴 Bogota, Colombia

Hospital Universitario de San Ignacio; 🇨🇴 Santa Fe De Bogotá, Colombia

Kardiologie MUDr. Libor Nechvatal s.r.o.; 🇨🇿 Brno, Czechia

Kardiologicka ambulance Brno s.r.o.; 🇨🇿 Brno, Czechia

Kardio Chlumec s.r.o.- Kardiologicka ambulance; 🇨🇿 Chlumec nad Cidlinou, Czechia

Fakultni nemocnice Brno; 🇨🇿 Brno, Czechia

Kardiologicka ambulance; 🇨🇿 Cesky Krumlov, Czechia

Poliklinika Dolni Brezany; 🇨🇿 Dolni Brezany, Czechia

Fakultni Nemocnice Hradec Kralove; 🇨🇿 Hradec kralove, Czechia

LUNACOR, Centrum pro choroby srdce a cev; 🇨🇿 Kromeriz, Czechia

Kromerizska nemocnice a.s.; 🇨🇿 Kromeriz, Czechia

KardioBusak s.r.o.; 🇨🇿 Louny, Czechia

Fakultni nemocnice Plzen; 🇨🇿 Plzen, Czechia

Krajska Nemocnice Liberec; 🇨🇿 Liberec, Czechia

Kardiologicka a interni ambulance; 🇨🇿 Pisek, Czechia

Polabska zdravotni, s.r.o.; 🇨🇿 Podebrady, Czechia

Midwest Cardiovascular Research and Education Foundation; 🇺🇸 Elkhart, Indiana, United States

Advocate Condell Medical Center; 🇺🇸 Libertyville, Illinois, United States

Baptist Health Paducah; 🇺🇸 Paducah, Kentucky, United States

Affidea Praha s.r.o; 🇨🇿 Praha 11 - Chodov, Czechia

Vseobecna fakultni nemocnice v Praze; 🇨🇿 Praha 2, Czechia

Institut Klinicke a Experimentalni Mediciny; 🇨🇿 Praha 4, Czechia

Fakultni nemocnice v Motole; 🇨🇿 Praha 5, Czechia

Kardio s.r.o.; 🇨🇿 Trebic, Czechia

Ustredni vojenska nemocnice Praha; 🇨🇿 Praha 6, Czechia

Nemocnice Podlesi; 🇨🇿 Trinec, Czechia

Nemocnice Znojmo; 🇨🇿 Znojmo, Czechia

Aarhus Universitetshospital, Skejby; 🇩🇰 Aarhus N, Denmark

Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed; 🇩🇰 Esbjerg, Denmark

Angiocor s.r.o.; 🇨🇿 Zlin, Czechia

Capital Region | Gentofte Hospital - Cardiology Research; 🇩🇰 Hellerup, Denmark

Capital Region | Herlev Hospital - Department of Heart Disease; 🇩🇰 Herlev, Denmark

HUS Jorvin sairaala; 🇫🇮 Espoo, Finland

Holbæk Sygehus; 🇩🇰 Holbæk, Denmark

Hvidovre Hospital; 🇩🇰 Hvidovre, Denmark

Regionshospitalet Randers; 🇩🇰 Randers, Denmark

Tampereen yliopistollinen sairaala, keskussairaala; 🇫🇮 Tampere, Finland

Klinikum der Universität Würzburg; 🇩🇪 Würzburg, Bayern, Germany

Turun yliopistollinen keskussairaala; 🇫🇮 Turku, Finland

Herzklinik Ulm GbR; 🇩🇪 Ulm, Baden-Württemberg, Germany

Sana-Klinikum Remscheid GmbH; 🇩🇪 Remscheid, Nordrhein-Westfalen, Germany

Medizinische Hochschule Hannover (MHH); 🇩🇪 Hannover, Niedersachsen, Germany

Forschungszentrum Ruhr - KliFoCenter GmbH; 🇩🇪 Witten, Nordrhein-Westfalen, Germany

General Hosp of Athens "Korgialenio-Benakeio" RCH; 🇬🇷 Ampelokipi - Athens, Greece

KAT General Hospital of Athens; 🇬🇷 Kifisia / Athens, Attica, Greece

HIPPOKRATION General Hospital of Athens; 🇬🇷 Athens, Greece

University General Hospital of Alexandroupolis; 🇬🇷 Alexandroupoli, Greece

General Hospital of Athens "ALEXANDRA"; 🇬🇷 Athens, Greece

University General Hospital of Heraklion; 🇬🇷 Heraklion, Greece

University General Hospital ATTIKON; 🇬🇷 Chaidari, Greece

University General Hospital of Larissa; 🇬🇷 Larissa, Greece

Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA; 🇬🇷 Nea Ionia / Athens, Greece

Hippokration General Hospital of Thessaloniki; 🇬🇷 Thessaloniki, Greece

University General Hospital of Patra; 🇬🇷 Patra, Greece

Princess Margaret Hospital; 🇭🇰 Lai Chi Kok, Hong Kong

Cardiomobile Egeszsegugyi Szolgaltato Kft.; 🇭🇺 Balatonfured, Hungary

Budapesti Uzsoki Utcai Korhaz; 🇭🇺 Budapest, Hungary

University of Semmelweis/ Semmelweis Egyetem; 🇭🇺 Budapest, Hungary

Eszak-Pesti Centrumkorhaz-Honvedkorhaz; 🇭🇺 Budapest, Hungary

Csongrad-Csanad Varmegyei Egeszsegugyi Ellato Kozpont Hodmezovasarhelyi Tagintezmeny; 🇭🇺 Hodmezovasarhely, Hungary

Budai Irgalmasrendi Korhaz; 🇭🇺 Budapest, Hungary

Bugat Pal Korhaz; 🇭🇺 Gyongyos, Hungary

Pharma4Trial Kft.; 🇭🇺 Gyongyos, Hungary

Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet; 🇭🇺 Budapest, Hungary

Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz; 🇭🇺 Miskolc, Hungary

Nagykanizsai Kanizsai Dorottya Korhaz; 🇭🇺 Nagykanizsa, Hungary

Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.; 🇭🇺 Nyiregyhaza, Hungary

Coromed Smo Kft; 🇭🇺 Pecs, Hungary

SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont; 🇭🇺 Szeged, Hungary

Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz; 🇭🇺 Szekesfehervar, Hungary

Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz; 🇭🇺 Szentes, Hungary

Max Super Speciality Hospital, Saket; 🇮🇳 New Delhi, Delhi, India

Safdarjung Hospital; 🇮🇳 New Delhi, Delhi, India

Barzilai Ashkelon University Medical Center | Cardiology Department; 🇮🇱 Ashkelon, Israel

Lady Davis Carmel Medical Center; 🇮🇱 Haifa, Israel

Bnai Zion Medical Center | Cardiology Department; 🇮🇱 Haifa, Israel

Hadassah Hebrew University Hospital Ein Kerem; 🇮🇱 Jerusalem, Israel

Madras Medical Mission Institute; 🇮🇳 Chennai, Tamil Nadu, India

KEM hospital; 🇮🇳 Pune, Maharashtra, India

Assuta Ashdod; 🇮🇱 Ashdod, Israel

Meir Medical Center; 🇮🇱 Kfar Saba, Israel

Health Corporation of Galilee Medical Center; 🇮🇱 Nahariya, Israel

Chaim Sheba Medical Center; 🇮🇱 Ramat Gan, Israel

Poria Medical Center | Cardiovascular Department; 🇮🇱 Lower Galilee, Israel

Kaplan Medical Center; 🇮🇱 Rehovot, Israel

Health Corporation of the Ziv Medical Center (R.A.); 🇮🇱 Zefat, Israel

Tel-Aviv Sourasky Medical Center; 🇮🇱 Tel Aviv, Israel

Shamir Medical Center (Assaf Harofeh); 🇮🇱 Zrifin, Israel

A.O.U. Mater Domini; 🇮🇹 Catanzaro, Calabria, Italy

AUSL di Bologna; 🇮🇹 Bologna, Emilia-Romagna, Italy

A.O.U. di Ferrara; 🇮🇹 Ferrara, Emilia-Romagna, Italy

AUSL di Piacenza; 🇮🇹 Piacenza, Emilia-Romagna, Italy

ASST Papa Giovanni XXIII; 🇮🇹 Bergamo, Lombardia, Italy

ASST di Cremona; 🇮🇹 Cremona, Lombardia, Italy

ASST del Garda; 🇮🇹 Brescia, Lombardia, Italy

IRCCS Centro Cardiologico Monzino; 🇮🇹 Milano, Lombardia, Italy

ASST di Monza; 🇮🇹 Monza Brianza, Lombardia, Italy

ASST della Brianza; 🇮🇹 Monza Brianza, Lombardia, Italy

ASST Spedali Civili di Brescia; 🇮🇹 Brescia, Lombardia, Italy

Istituto Clinico Humanitas - Humanitas Mirasole S.p.A.; 🇮🇹 Milano, Lombardia, Italy

IRCCS Istituti Clinici Scientifici Maugeri SpA SB; 🇮🇹 Milano, Lombardia, Italy

Fondazione IRCCS Policlinico San Matteo; 🇮🇹 Pavia, Lombardia, Italy

AUSL Toscana Sud-Est; 🇮🇹 Arezzo, Toscana, Italy

ASST Sette Laghi; 🇮🇹 Varese, Lombardia, Italy

A.O.U. Senese; 🇮🇹 Siena, Toscana, Italy

Ogaki Municipal Hospital; 🇯🇵 Ogaki, Gifu, Japan

Kasugai Municipal Hospital; 🇯🇵 Kasugai, Aichi, Japan

A.O.U.I. Verona; 🇮🇹 Verona, Veneto, Italy

Steel Memorial Yawata Hospital; 🇯🇵 Kitakyushu, Fukuoka, Japan

JA Toride Medical Center; 🇯🇵 Toride, Ibaraki, Japan

National Hospital Organization Kobe Medical Center; 🇯🇵 Kobe, Hyogo, Japan

Higashi Takarazuka Satoh Hospital; 🇯🇵 Takarazuka, Hyogo, Japan

Mitoyo General Hospital | Kagawa, Japan; 🇯🇵 Kanonji, Kagawa, Japan

Iwate Prefectural Central Hospital; 🇯🇵 Morioka, Iwate, Japan

Sagamihara Kyodo Hospital; 🇯🇵 Sagamihara, Kanagawa, Japan

Takatsuki Red Cross Hospital; 🇯🇵 Takatsuki, Osaka, Japan

Kawaguchi Cardiovascular and Respiratory Hospital; 🇯🇵 Kawaguchi, Saitama, Japan

National Hospital Organization Hamada Medical Center; 🇯🇵 Hamada, Shimane, Japan

Nishiarai Heart Central Clinic; 🇯🇵 Adachi-ku, Tokyo, Japan

Minamino Cardiovascular Hospital; 🇯🇵 Hachioji, Tokyo, Japan

National Hospital Organization Iwakuni Clinical Center; 🇯🇵 Iwakuni, Yamaguchi, Japan

Japan Organization of Occupational Health and Safety Sanin Rosai Hospital; 🇯🇵 Yonago, Tottori, Japan

JCHO Shimonoseki Medical Center; 🇯🇵 Shimonoseki, Yamaguchi, Japan

Gifu Prefectural General Medical Center; 🇯🇵 Gifu, Japan

Shinrakuen Hospital; 🇯🇵 Niigata, Japan

Miyazaki Medical Association Hospital; 🇯🇵 Miyazaki, Japan

Osaka Police Hospital | Clinical Research and Trial Center; 🇯🇵 Osaka, Japan

Social Corporation Keigakukai Minamiosaka Hospital; 🇯🇵 Osaka, Japan

Seiyu Memorial Hospital; 🇯🇵 Wakayama, Japan

Chungbuk National University Hospital; 🇰🇷 Cheongju-si, Chungcheongbugdo, Korea, Republic of

Bundang Cha Hospital; 🇰🇷 Seongnam-si, Gyeonggido, Korea, Republic of

Yonsei University Wonju Christian Hospital; 🇰🇷 Wonju, Gang''weondo, Korea, Republic of

Hallym University Sacred Heart Hospital; 🇰🇷 Anyang, Gyeonggido, Korea, Republic of

Dong-A University Hospital; 🇰🇷 Busan, Korea, Republic of

Chung Nam National University Hospital; 🇰🇷 Daejeon, Korea, Republic of

Daugavpils Regional Hospital; 🇱🇻 Daugavpils, Latvia

1st Riga Clinical Hospital; 🇱🇻 Riga, Latvia

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of

Chonnam National University Hospital; 🇰🇷 Gwangju, Korea, Republic of

Jelgava Outpatient Clinic; 🇱🇻 Jelgava, Latvia

Liepaja Regional Hospital; 🇱🇻 Liepaja, Latvia

P. Stradins Clinical University Hospital; 🇱🇻 Riga, Latvia

GK Neiroklinika; 🇱🇻 Riga, Latvia

LUHS Kauno Hospital (Laisves ave.); 🇱🇹 Kaunas, Lithuania

Klaipedos Jurininku Ligonine; 🇱🇹 Klaipeda, Lithuania

Gita Rancane - cardiology private practice; 🇱🇻 Ventspils, Latvia

UAB "Klinikiniai sprendimai" Alytus; 🇱🇹 Alytus, Lithuania

LUHS Kauno Hospital (Josvainiu str.); 🇱🇹 Kaunas, Lithuania

Siauliai Republican hospital; 🇱🇹 Siauliai, Lithuania

Vilnius University Hospital Santaros Klinikos; 🇱🇹 Vilnius, Lithuania

Institute Jantung Negara; 🇲🇾 Kuala Lumpur, Malaysia

University Malaya Medical Centre; 🇲🇾 Kuala Lumpur, Malaysia

Hospital General de Acapulco; 🇲🇽 Acapulco, Guerrero, Mexico

Ziekenhuis Groep Twente; 🇳🇱 Almelo, Netherlands

Hospital de Jesús; 🇲🇽 Alcaldía Cuauhtemoc, Distrito Federal, Mexico

Consultorio de Medicina Especializada del Sector Privado; 🇲🇽 Guadalajara, Jalisco, Mexico

Hospital Cardiologica Aguascalientes; 🇲🇽 Aguascalientes, Mexico

Slingeland Ziekenhuis; 🇳🇱 Doetinchem, Netherlands

Deventer Ziekenhuis; 🇳🇱 Deventer, Netherlands

Ziekenhuis St. Jansdal; 🇳🇱 Harderwijk, Netherlands

Antonius Ziekenhuis Sneek; 🇳🇱 Sneek, Netherlands

Hutt Hospital; 🇳🇿 Lower Hutt, New Zealand

P3 Research Ltd Hawkes Bay; 🇳🇿 Hawkes Bay, New Zealand

Christchurch Heart Institute; 🇳🇿 Christchurch, New Zealand

P3 Research; 🇳🇿 Tauranga, New Zealand

MICS Centrum Medyczne Bydgoszcz; 🇵🇱 Bydgoszcz, Poland

Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej; 🇵🇱 Gdynia, Poland

Samodzielny Publiczny Specjalistyczny Szpital Zachodni; 🇵🇱 Grodzisk Mazowiecki, Poland

CLINICAL MEDICAL RESEARCH Sp. z o. o.; 🇵🇱 Katowice, Poland

Uniwersytecki Szpital Kliniczny w Poznaniu; 🇵🇱 Poznan, Poland

Gessek Jacek Prywatny Gabinet Lekarski; 🇵🇱 Torun, Poland

Hospital da Senhora da Oliveira | Clinical Research Department; 🇵🇹 Guimaraes, Braga, Portugal

BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos; 🇵🇹 Aveiro, Portugal

Hospital Prof. Dr. Fernando Fonseca; 🇵🇹 Amadora, Portugal

ULSG - Unidade Local de Saude da Guarda; 🇵🇹 Guarda, Portugal

Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica; 🇵🇹 Lisboa, Portugal

Spitatul Universitar de Urgenta Bucaresti; 🇷🇴 Bucharest, Romania

Spitalul Clinic Municipal de Urgenta "Timisoara"; 🇷🇴 Timisoara, Timis, Romania

Timisoara Institute of Cardiovascular Diseases; 🇷🇴 Timisoara, Romania

Municipal Clinical Emergency Hospital of Timisoara; 🇷🇴 Timisoara, Romania

S.C. Cardio Med S.R.L.; 🇷🇴 Targu Mures, Romania

First City Clinical Hospital n.a. E.E. Volosevich; 🇷🇺 Arkhangelsk, Russian Federation

SBEI "Chita State Medical Academy"; 🇷🇺 Chita, Russian Federation

Altai Regional Cardiological Dispensary; 🇷🇺 Barnaul, Russian Federation

Sci-Res. Institute of Complex Cardiovascular Disorders; 🇷🇺 Kemerovo, Russian Federation

Clinical Diagnostic Center; 🇷🇺 Kazan, Russian Federation

Center of cardiology and neurology; 🇷🇺 Kirov, Russian Federation

City clinical hospital n.a. V.V. Vinogradov; 🇷🇺 Moscow, Russian Federation

Moscow State University n.a. M.V. Lomonosov; 🇷🇺 Moscow, Russian Federation

SBI of the Ryazan region "Regional clinical hospital"; 🇷🇺 Ryazan, Russian Federation

State Novosibirsk Regional Clinical Hospital; 🇷🇺 Novosibirsk, Russian Federation

Russian Clinical and Research Center of Gerontology; 🇷🇺 Moscow, Russian Federation

Perm Regional Hospital for War Veterans; 🇷🇺 Perm, Russian Federation

Penza Regional Clinical Hospital n.a. N.N. Burdenko; 🇷🇺 Penza, Russian Federation

Rostov-on-Don Emergency Clinical Hospital; 🇷🇺 Rostov-on-Don, Russian Federation

Samara Regional Clinical Cardiology Dispensary n.a. Polyakov; 🇷🇺 Samara, Russian Federation

Scien. Res. Inst. of Emergency Care n.a. I.I. Dzhanelidze; 🇷🇺 St. Petersburg, Russian Federation

Tomsk Regional Clinical Hospital; 🇷🇺 Tomsk, Russian Federation

Clinical Hospital #3 n.a. S.R. Mirotvortsev; 🇷🇺 Saratov, Russian Federation

Scientific Research Institute of Cardiology; 🇷🇺 Tomsk, Russian Federation

St. Petersburg Clinical Hospital of RAS; 🇷🇺 St. Petersburg, Russian Federation

Sverdlovsk Regional Clinical Hospital #1; 🇷🇺 Yekaterinburg, Russian Federation

LLC Astarta; 🇷🇺 St. Petersburg, Russian Federation

ALIAN s.r.o.; 🇸🇰 Bardejov, Slovakia

Centrum interv. neuroradiologie a endovaskularnej liecby; 🇸🇰 Bratislava, Slovakia

Kardiosanus | Bratislava, Slovakia; 🇸🇰 Bratislava, Slovakia

KARDIO-ANGIO s.r.o.; 🇸🇰 Levice, Slovakia

Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department; 🇸🇰 Nitra, Slovakia

Nemocnica s poliklinikou Brezno, n.o.; 🇸🇰 Brezno, Slovakia

Medical Group Kosice s.r.o. | Kosice, Slovakia; 🇸🇰 Kosice, Slovakia

Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke Prevention; 🇪🇸 L'Hospitalet de Llobregat, Barcelona, Spain

MEDISPOL s.r.o.; 🇸🇰 Presov, Slovakia

Hospital Santa María del Puerto; 🇪🇸 El Puerto de Santa María, Cádiz, Spain

Hospital Alta Resolucion de Utrera | Cardiology Service Department; 🇪🇸 Utrera, Sevilla, Spain

Ciutat Sanitaria i Universitaria de la Vall d'Hebron; 🇪🇸 Barcelona, Spain

Hospital Universitario Virgen de las Nieves|Cardiologia; 🇪🇸 Granada, Spain

Hospital del Mar; 🇪🇸 Barcelona, Spain

Hospital Sanitas La Zarzuela | Cardiologia; 🇪🇸 Madrid, Spain

Hospital Ramón y Cajal | Medicina Interna; 🇪🇸 Madrid, Spain

Complejo Hospitalario Ntra. Sra. de Valme; 🇪🇸 Sevilla, Spain

Hospital San Rafael; 🇪🇸 Salvador, Spain

Hospital Clínico Universitario de Valencia; 🇪🇸 Valencia, Spain

Hospital General Universitario de Valencia; 🇪🇸 Valencia, Spain

Hospital de Manises; 🇪🇸 Valencia, Spain

La Fe University and Polytechnic Hospital | Cardiology Department; 🇪🇸 Valencia, Spain

Taipei Veterans General Hospital; 🇨🇳 Taipei, Taiwan

Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital; 🇨🇳 Kaohsiung City, Kaohsiung, Taiwan

Mackay Memorial Hospital - Hsinchu Branch; 🇨🇳 Hsinchu, Taiwan

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan

Changhua Christian Hospital; 🇨🇳 Changhua, Taiwan

Taipei Medical University Hospital; 🇨🇳 Taipei, Taiwan

Istanbul Universitesi Kardiyoloji Enstitusu; 🇹🇷 Istanbul, Turkey

Afyonkarahisar Saglik Bilimleri Universitesi; 🇹🇷 Afyonkarahisar, Turkey

Saglik Bilimleri Universitesi Antalya EA Hastanesi; 🇹🇷 Antalya, Turkey

Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.; 🇹🇷 Istanbul, Turkey

Dokuz Eylul Universitesi Tip Fakultesi; 🇹🇷 Izmir, Turkey

Eskisehir Osmangazi Universitesi Tip Fakultesi; 🇹🇷 Eskisehir, Turkey

Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi; 🇹🇷 Istanbul, Turkey

Erciyes Universitesi Tip Fakultesi; 🇹🇷 Kayseri, Turkey

Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi; 🇹🇷 Konya, Turkey

Kocaeli Universitesi Tip Fakultesi; 🇹🇷 Kocaeli, Turkey

Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti; 🇹🇷 Kutahya, Turkey

Mersin Universitesi Tip Fakultesi; 🇹🇷 Mersin, Turkey

City Clinical Hospital # 1; 🇺🇦 Kiev, Ukraine

Cherkasy Regional Cardiological Center; 🇺🇦 Cherkasy, Ukraine

"Clinical Emergency Hospital" of Dnipro City Council; 🇺🇦 Dnipro, Ukraine

National Institute of Therapy named after L.T.Maloyi; 🇺🇦 Kharkiv, Ukraine

LLC Medical Centre CONSILIUM MEDICAL; 🇺🇦 Kyiv, Ukraine

Railway Clinical Hospital #2; 🇺🇦 Kyiv, Ukraine

Medbud-Clinic LLC; 🇺🇦 Kyiv, Ukraine

Lviv regional clinical medical & diagnostic cardiology cente; 🇺🇦 Lviv, Ukraine

Vinnytsia City Clinical Hospital #1; 🇺🇦 Vinnytsia, Ukraine

Zakarpatsky Oblasnyi Kardiologichnyi Dyspanser; 🇺🇦 Uzhgorod, Ukraine

Communal Institution Central City Hospital 1 of Zhytomyr; 🇺🇦 Zhytomyr, Ukraine

Regional medical center of cardio-vascular disease; 🇺🇦 Zaporizhzhja, Ukraine

Zaporizhzhya City Emergency Care Hospital; 🇺🇦 Zaporizhzhya, Ukraine

Poole Hospital NHS Trust; 🇬🇧 Poole, Dorset, United Kingdom

Queen Elizabeth University Hospital; 🇬🇧 Glasgow, Glasgow City, United Kingdom

Lister Hospital; 🇬🇧 Stevenage, Hertfordshire, United Kingdom

Russells Hall Hospital; 🇬🇧 Dudley, West Midlands, United Kingdom

St Richard's Hospital; 🇬🇧 Chichester, West Sussex, United Kingdom

Manchester Royal Infirmary; 🇬🇧 Manchester, United Kingdom

Glasgow Royal Infirmary | Glasgow Clinical Research Facility; 🇬🇧 Glasgow, United Kingdom

Great Western Hospital; 🇬🇧 Swindon, United Kingdom

Division of Cardiovascular Research at Peconic Bay Med Ctr; 🇺🇸 Riverhead, New York, United States

Reid Physician Associates | Cardiology Department; 🇺🇸 Richmond, Indiana, United States

Campinas Clinical Research Institute (IPECC) | Campinas, Brazil; 🇧🇷 Campinas, Sao Paulo, Brazil

Flinders Medical Centre; 🇦🇺 Bedford Park, South Australia, Australia

Kernodle Clinic West, Private Diagnostic Clinic PLLC; 🇺🇸 Burlington, North Carolina, United States

Sutter Heart & Vascular Institute; 🇺🇸 Sacramento, California, United States

Wake Forest Baptist Health; 🇺🇸 Winston-Salem, North Carolina, United States

Severance Hospital, Yonsei University Health System; 🇰🇷 Seoul, Korea, Republic of

University of North Carolina; 🇺🇸 Chapel Hill, North Carolina, United States

Seton Heart Institute; 🇺🇸 Austin, Texas, United States

Malcom Randall VA Medical Ctr; 🇺🇸 Gainesville, Florida, United States

Clinical Research Consultants; 🇺🇸 Kansas City, Missouri, United States

St. Luke's Mid America Heart Institute; 🇺🇸 Kansas City, Missouri, United States

Cardiac Care & Vascular Medicine; 🇺🇸 Bronx, New York, United States

William S. Middleton Memorial Veterans Hospital; 🇺🇸 Madison, Wisconsin, United States

Instituto Médico de la Fundación Estudios Clinicos; 🇦🇷 Rosario, Santa Fe, Argentina

Research center of therapy and prophylactic medicine; 🇷🇺 Moscow, Russian Federation

Fundación Cardiomet CEQUIN Eje Cafetero; 🇨🇴 Armenia, Quindío, Colombia

Castle Hill Hospital; 🇬🇧 Cottingham, United Kingdom

Queen Elizabeth II Health Sciences Centre; 🇨🇦 Halifax, Nova Scotia, Canada

Queen Mary Hospital; 🇭🇰 Hong Kong, Hong Kong

Queen Elizabeth Hospital Hong Kong; 🇭🇰 Kowloon, Hong Kong

Prince of Wales Hospital; 🇭🇰 Shatin, N.T, Hong Kong