ISRCTN11314056已完成未知
Modulation of ventrolateral prefrontal cortical activity during reward processing by transcranial direct current stimulation
niversity of Pittsburgh0 个研究点目标入组 58 人开始时间: 2019年2月13日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 58
研究概览
简要总结
2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31664174 (added 24/01/2020)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •All participants:
- •1. Right-handed (Annett criteria)
- •2. Aged 18-45 years
- •3. Able to give basic informed consent
- •4. Women of childbearing potential must agree to a urine pregnancy test
- •Adults with no psychiatric history (healthy controls):
- •5. No previous/present psychiatric history of any disorder including Substance Use Disorders (SCID-5 criteria)
- •6. No family history of psychiatric illness (Family History Questionnaire criteria)
- •Adults with Bipolar Disorder I (BDI):
- •7. In remission with a diagnosis of BDI (DSM-5 criteria; euthymic for more than 2 months)
- •8. Any antidepressant, any mood stabilizer, any atypical antipsychotic, or any combination of atypical antipsychotics and/or mood stabilizers and/or antidepressants taken for 2 months or longer or unmedicated individuals
排除标准
- •All participants:
- •1. Not native English speaking or not fluent
- •2. History of head injury/severe concussion, neurological, pervasive developmental disorder (e.g. autism), or systemic medical disease (that could impact fMRI scans; from medical records and report by each potential participant)
- •3. Mini-Mental State Examination (cognitive state) score <24
- •4. Premorbid NAART IQ estimate <85
- •5. Visual disturbance (<20/40 Snellen visual acuity) with correction or either contacts or glasses
- •6. Left/mixed handedness (Annett criteria), to ensure a uniform hemispheric dominance for interpretation of neuroimaging data
- •7. MRI screening: to exclude individuals with ferromagnetic foreign objects, e.g., surgical implants, and individuals prone to claustrophobia; and a positive pregnancy test for females (performed at the MRRC) or self-report pregnancy; being too physically large to fit in the scanner (greater than 55 inches chest circumference)
- •8. Active suicidal ideation
- •Adults with Bipolar Disorder I (BDI):
- •9. Not being in remission with a diagnosis of BDI (DSM-5 criteria; euthymic for 2 months or less)
- •10. If medicated, not on any combination of atypical antipsychotics and/or mood stabilizers and/or antidepressants taken for two months or longer
- •11. History of alcohol/substance abuse/dependence (including nicotine) and/or illicit substance use (except cannabis) over the last 3 months, determined by Structured Clinical Interview for DSM-5 (SCID-5). Lifetime/present cannabis use (non-abuse levels) will be allowed, given its common usage in individuals with BD. Urine tests on the scan day will exclude individuals with current illicit substance use (except cannabis); salivary alcohol tests will exclude individuals who are intoxicated on the scan day. Alcohol/nicotine/caffeine/cannabis use (below SCID-5 abuse/dependence levels) per week will be allowed, recorded for all individuals
- •12. Score >7 on the Hamilton Rating Scale for Depression (HRDS)
- •13. Score >10 on the Young Mania Rating Scale (YMRS)
- •14. Psychotic: Score of 3 or more on suspiciousness, hallucinations, unusual thought content subscales of the Brief Psychiatric Rating Scale (BPRS)
- •Adults with no psychiatric history (healthy controls):
- •15. Lifetime history of alcohol/substance abuse/dependence (including nicotine) and/or illicit substance use (except cannabis), determined by Structured Clinical Interview for DSM-5 (SCID-5)(50). Urine tests on the scan day will exclude individuals with current illicit substance use (except cannabis); salivary alcohol tests will exclude individuals who are intoxicated on the scan day. Alcohol/nicotine/caffeine/cannabis use (below SCID-5 abuse/dependence levels) per week will be allowed, recorded for all individuals
- •16. Lifetime history of psychotropic medicine use
- •17. First degree relative with Axis I disorder
- •18. Present/previous personal history of psychiatric illness in childhood or after the age of 18 years (SCID-I)
研究者
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