Role of remote ischemia preconditioning in reducing myocardial injury in chronic kidney disease patients on maintenance hemodialysis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 154
- 试验地点
- 1
- 主要终点
- Reduction in cardiac injury during dialysis assessed using trop I levels
研究概览
简要总结
Chronic kidney disease patients on maintance hemodialysis are at increased risk of cardiovascular disease. Mortality occurs in these patients due to cardiovascular diseases. Even during hemodialysis, these patients are prone to myocardial injury which can affect their cardiac health. all measures which can reduce the myocardial injury in these group of patients have to be sought. remote ischemia preconditioning, which is easy to perform, is considered to be one such measure. this study aims to look for the benefit of remote ischemia preconditioning intervention in reducing myocardial injury in hemodialysis patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- Male
入选标准
- •CKD stage 5 patients on maintenance hemodialysis Age between 18 to 65.
排除标准
- •Patients who had acute coronary syndrome, stable angina pectoris, or decompensated heart failure in the 6 months before inclusion Overt cardiac failure: NYHA CLASS 3 and CLASS 4 Patients with cerebrovascular disease, chronic liver disease, gastrointestinal bleed, malignancy Current smoker Patients with cardiac event during study period Patients developing intradialytic hypotension requiring inotropic support Patients not willing to participate in study.
结局指标
主要结局
Reduction in cardiac injury during dialysis assessed using trop I levels
时间窗: At 3rd, 7th day and at the end of study
次要结局
- not applicable(not applicable)
研究者
Prasoon Sebastian
GOVERNMENT MEDICAL COLLEGE KOZHIKKODE