King's invasive aspergillosis study II (KIASII)

Phase 4

Completed

• Conditions: Specialty: Haematology, Primary sub-specialty: Haematology; UKCRC code/ Disease: Infection/ Other bacterial diseases; Infections and Infestations; Invasive fungal disease

• Registration Number: ISRCTN11847553
• Lead Sponsor: King's College Hospital NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-06-07
• Study Completion: 2019-10-27
• Last Update Posted: 1 March 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Adult = 18 years
2. Patients with aplastic anaemia, MDS or AML undergoing:
2.1. IST; or
2.2. Intensive chemotherapy such as induction chemotherapy; or
2.3. RIC allogeneic HSCT
3. Able to swallow and retain orally administered medication

Exclusion Criteria

1. Refusal or inability to consent
2. Autologous HSCT
3. Contraindicated medications
4. Current evidence of IFD diagnosis or treatment
5. Women who are pregnant or lactating
6. Enrolled in another study requiring alternative antifungal prophylaxis or treatment
7. Women who are unable to use and apply with effective contraception without interruption throughout the duration of study drug therapy and not willing to have further pregnancy tests during the course of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified