A glucagon challenge in healthy volunteers - A glucagon challenge in healthy volunteers

Centre for Human Drug Research0 个研究点目标入组 8 人开始时间: 待定最近更新: 2024年5月13日

适应症

试验速览

暂无简介。

•- Clinically significant abnormalities in medical history, physical examination or
•laboratory examination
•- Pregnanant or breast feeding females
•- Not able or willing to use an acceptable contraceptive method for study duration
•for females (hormonal contraceptives, intra-uterine device or condom/pessary)
•- Not able and willing to refrain from smoking and/or xanthine use on study day
•- Fasting plasma glucose at screening >= 6.4
•- HbA1C >= 7%
•- BMI >= 30 kg/m2
•- Hypertension (systolic blood pressure >= 140 mm Hg or a diastolic blood pressure >=
•- Suspicion of a pheochromocytoma (i.e. Rapid heart rate, palpitations, excessive
•sweating, chest pain, upper abdominal pain, severe headaches, tremors, feeling
•of anxiety or extreme fright, pale skin)
•- Positive urine testing for cocaine, opiates (morphine) and/or THC at screening
•- Use of concomitant medication (except hormonal contraceptives)
•- Positive test result for HIV, hepatitis B virus, and/or hepatitis C virus
•- History of alcohol or drug abuse
•- Undergoing or have undergone treatment with another investigational drug,
•biologic agent or device within 90 days prior to Screening.
•- Blood donation within three months of screening

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