Preterm Infants May Better Tolerate Feeds at Temperatures Closer to Freshly Expressed Breast Milk- A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prematurity
- Sponsor
- Ege University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Gastric residual volume in mililitres after every feeding
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Feeding intolerance is frequent among preterm infants in neonatal intensive care units (NICUs). Although there are many studies about enteral nutrition strategies and content in preterm infants, no evidence-based standards exist for the optimal milk temperature for preterm infants. Therefore, in this study the investigators aimed to examine the effects of feeding temperature and the possible morbidities.
Detailed Description
Feeding intolerance is one of the most frequent problems among preterm infants. These infants are fed with expressed breast milk or preterm formulas of which the temperature is not routinely measured. In this study, the investigators aimed to examine the effects of feeds with warm versus room temperature milk in preterm infants. Infants with a birth weight of ≤1500 g or gestational age of ≤ 34 weeks were included in the study and assigned to two different feeding temperature groups (22-24°C and 32-34°C). Some infants in both groups were exclusive breast milk fed and some received artificial milk. Feeding tolerance of patients in both groups and the consequences were evaluated.
Investigators
Ozge Altun Koroglu
Associated Professor, M.D.
Ege University
Eligibility Criteria
Inclusion Criteria
- •Infants born to birth weight of ≤1500 g
- •Infants born to gestational age of ≤ 34 weeks
Exclusion Criteria
- •Genetic syndrome
- •Gastrointestinal system anomalies
- •Patients born small for their gestational age
Outcomes
Primary Outcomes
Gastric residual volume in mililitres after every feeding
Time Frame: through study completion, an average of 6 months
Gastric residual volume amount during the study
Secondary Outcomes
- Body weight at discharge(through study completion, an average of 6 months)
- Transition time to total enteral feeding(through study completion, an average of 6 months)
- Need for anti reflux treatment(through study completion, an average of 6 months)
- Daily weight gain(through study completion, an average of 6 months)