NCT00120380终止4 期
Combination Therapy of Bosentan and Aerosolized Iloprost in Idiopathic Pulmonary Arterial Hypertension
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- 6 minute walk test
研究概览
简要总结
The purpose of this study is to test whether the addition of inhaled iloprost is safe and effective in patients with idiopathic pulmonary arterial hypertension who are already being treated with the endothelin receptor antagonist bosentan.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 3 months treatment with bosentan
- •6 minute walk distance 150 - 425 m
排除标准
- •other forms of pulmonary hypertension
- •severe comorbidities
- •cotreatment with sildenafil or investigational drugs
研究组 & 干预措施
Aerosolized Iloprost
Active Comparator
干预措施: Aerosolized iloprost (Drug)
Bosentan monotherapy
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
6 minute walk test
次要结局
未报告次要终点
研究者
研究点 (1)
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