Diagnostic Value of Annexin V, sVCAM-1, sICAM-1, Vascular Endothelial Growth Factor, TNF Alpha and Interleukin-6 in Ovarian and Deep Infiltrating Endometriosis, the Changes of These Markers in the Postoperative Period
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 79
- 试验地点
- 1
- 主要终点
- Diagnostic value of serum sICAM-1 in endometriosis
研究概览
简要总结
The diagnostic value of Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and Proinflammatory cytokines (TNF-a and interleukin-6) in ovarian endometriosis and deep infiltrating endometriosis, their levels in organ-specific involvement, their relationship with symptoms, and the changes of these markers in the postoperative period will be evaluated.
详细描述
Serum Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and proinflammatory cytokines (TNF-a and interleukin-6) values were studied by taking blood samples from all patients before and three months after the operation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Stage III and IV endometriosis patients requiring surgery due to chronic pelvic pain or suspected malignancy
排除标准
- •Malignant disease
- •Ovarian failure
- •Acute pelvic inflammatory disease
- •Chronic autoimmune disease
结局指标
主要结局
Diagnostic value of serum sICAM-1 in endometriosis
时间窗: Up to 4 months
To determine whether serum sICAM-1(ng/mL) levels can be used as diagnostic markers of endometriosis disease.
Diagnostic value of serum Annexin V in endometriosis
时间窗: Up to 4 months
To determine whether serum Annexin V levels (ng/mL) can be used as diagnostic markers of endometriosis disease.
Diagnostic value of serum sVCAM-1 in endometriosis
时间窗: Up to 4 months
To determine whether serum sVCAM-1(ng/mL) levels can be used as diagnostic markers of endometriosis disease.
Diagnostic value of serum Vascular Endothelial Growth Factor in endometriosis
时间窗: Up to 4 months
To determine whether serum Vascular Endothelial Growth Factor (pg/mL) levels can be used as diagnostic markers of endometriosis disease.
Diagnostic value of serum Interleukin-6 in endometriosis
时间窗: Up to 4 months
To determine whether serum Interleukin-6 (pg/mL) levels can be used as diagnostic markers of endometriosis disease.
Diagnostic value of serum TNF-alpha in endometriosis
时间窗: Up to 4 months
To determine whether serum TNF-alpha (pg/mL) levels can be used as diagnostic markers of endometriosis disease.
次要结局
未报告次要终点
研究者
Evrim Ebru Kovalak
Medical Doctor, Obstetrician and Gynecologist
Bagcilar Training and Research Hospital