In vivo longitudinal evaluation of vertebral bone strength in patients with rheumatoid arthritis treated with alendronate

Not Applicable

Completed

• Conditions: Rheumatoid arthritis; Musculoskeletal Diseases

• Registration Number: ISRCTN95526224
• Lead Sponsor: Kyushu University, Department of Orthopaedic Surgery (Japan)

Brief Summary

2008 results in https://pubmed.ncbi.nlm.nih.gov/18975334/ (added 10/06/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2003-08-21
• Study Start: 2007-09-10
• Last Update Posted: 21 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

Female postmenopausal patients with RA who met the American College of Rheumatology diagnostic criteria for RA.

Exclusion Criteria

1. The presence of abnormalities on spinal radiographs such as severe osteophytosis, scoliosis, spinal fusion, fracture deformation
2. Any disease known to affect bone turnover
3. Current or past glucocorticoid therapy comprising greater than 7.5 mg/day (predonisone equivalent)
4. Current or past use of anabolic steroids, calcitonin, supplemental vitamin D or vitamin K, bisphosphonate
5. Current or past hormone replacement therapy
6. Spinal areal Bone Mineral Density (BMD) T-score greater than -1.0

Study & Design

• Study Type: Interventional
• Study Design: Not specified