Postoperative Infectious Complications Calculator for Elderly Patients--A Derivation and External Validation of Prediction Models Based on Two Centers Large Sample
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 37,230
- Locations
- 1
- Primary Endpoint
- Postoperative Infectious Complications Calculator for Elderly Patients
Study Overview
Brief Summary
The investigators established a first-ever convenient scoring system for clinicians to assess the risk of Postoperative infectious complications (PICs) for elderly patients. Our scoring system can aid in the early detection of potential risks for postoperative infections. Higher-score patients were more likely to experience postoperative infections.
Detailed Description
Background:
Postoperative infectious complications (PICs) are related to increased morbidity, mortality, and costs, especially in elderly patients. However, published prediction models of PICs are rarely based on elderly patients.
Objective
The study wanted to identify practical and valuable variables that could be used to predict postoperative infections and establish a convenient scoring system for clinicians to assess the risk of such conditions in elderly patients.
Methods： Data from 2 population-based cohorts of elderly patients undergoing non-cardiac and non-neurology surgery were used to derive and validate multivariable logistic regression models. The risk prediction models were derived from 37230 patients hospitalized in the First Medical Center of the Chinese PLA General Hospital (January 2014 - August 2019). The risk prediction models were externally validated with data from a cohort of 10252 patients hospitalized in Henan Provincial People's Hospital (November 2014 to May 2022).
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 65 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age ≥ 65 years and
- •patients undergoing surgery with anesthesia.
Exclusion Criteria
- •patients undergoing neurosurgery or cardiac surgery,
- •preoperative infectious diseases, and
- •patients with ≥50% of data missing.
Outcomes
Primary Outcomes
Postoperative Infectious Complications Calculator for Elderly Patients
Time Frame: January 2012 - August 2018
A Derivation and External Validation of Prediction Models based on two centers large sample
Secondary Outcomes
No secondary outcomes reported
Investigators
Weidong Mi
Director, Department of Anesthesiology, The First Medical Center
Chinese PLA General Hospital