Postoperative Infectious Complications Calculator for Elderly Patients

Completed

• Conditions: Postoperative Infection; Prediction; Geriatrics

• Registration Number: NCT06265493
• Lead Sponsor: Weidong Mi

Brief Summary

The investigators established a first-ever convenient scoring system for clinicians to assess the risk of Postoperative infectious complications (PICs) for elderly patients. Our scoring system can aid in the early detection of potential risks for postoperative infections. Higher-score patients were more likely to experience postoperative infections.

Detailed Description

Background:

Postoperative infectious complications (PICs) are related to increased morbidity, mortality, and costs, especially in elderly patients. However, published prediction models of PICs are rarely based on elderly patients.

Objective:

The study wanted to identify practical and valuable variables that could be used to predict postoperative infections and establish a convenient scoring system for clinicians to assess the risk of such conditions in elderly patients.

Methods： Data from 2 population-based cohorts of elderly patients undergoing non-cardiac and non-neurology surgery were used to derive and validate multivariable logistic regression models. The risk prediction models were derived from 37230 patients hospitalized in the First Medical Center of the Chinese PLA General Hospital (January 2014 - August 2019). The risk prediction models were externally validated with data from a cohort of 10252 patients hospitalized in Henan Provincial People's Hospital (November 2014 to May 2022).

Study Timeline

• Study Start: 2021-06-01
• Primary Completion: 2023-06-30
• Study Completion: 2023-09-30
• Study First Submitted: 2024-02-11
• Study First Submitted QC: 2024-02-16
• Study First Posted: 2024-02-20
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-03
• Last Update Posted: 2024-08-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37230

Inclusion Criteria

1. age ≥ 65 years and
2. patients undergoing surgery with anesthesia.

Exclusion Criteria

1. patients undergoing neurosurgery or cardiac surgery,
2. preoperative infectious diseases, and
3. patients with ≥50% of data missing.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative Infectious Complications Calculator for Elderly Patients	January 2012 - August 2018	A Derivation and External Validation of Prediction Models based on two centers large sample

Trial Locations

Locations (1)

Depatment of Anesthesiology, The First Medical Center Affiliation: Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China