The ACTIVate Study: Optimising activity and diet compositions for dementia preventio

Not Applicable

Recruiting

• Conditions: Dementia; Neurological - Dementias

• Registration Number: ACTRN12619001659190
• Lead Sponsor: Dr Ashleigh Smith

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-27
• Last Update Posted: 14 June 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 448

Inclusion Criteria

Community-dwelling adults aged 60-70 years who are fluent in the English language and meet safety criteria for TMS and MRI

Exclusion Criteria

Overall study exclusion criteria:
• Blindness, colour blindness or vision difficulties that cannot be corrected by glasses or contact lenses
• Major neurological or psychiatric diagnosis
• Known intellectual disability
• Major physical disability
• Previous head trauma resulting in a loss of consciousness of more than 5 minutes
• Current or previous alcohol or substance abuse or dependence
• Recreational drug use in the last 3 months
• Previous stroke or diagnosed transient ischemic attack
• Cancer treatment in the past 5 years
• Unable to undergo TMS or MRI assessments (detailed below), or unable to wear an EEG cap
• Scores below the mild cognitive impairment (MCI) cut-off on the Telephone Montreal Cognitive Assessment (T-MoCA) or a current diagnosis of dementia

TMS exclusion criteria:
• Current medications targeting the central nervous system (including anticonvulsants and antidepressants)
• History of epilepsy, convulsions or seizures
• History of severe head trauma followed by loss of consciousness
• Presence of metal in the brain or skull (excluding titanium) or a neurostimulator implant
• Cochlear implants
• Presence of pacemaker, intracardiac lines, implants or metals
• Presence of a medication infusion device
• History of surgical procedures to the spinal cord or any spinal or ventricular derivations

MRI exclusion criteria:
• Presence of a pacemaker
• Presence of metal implants, including aneurysm clips; brain shunt tubes; artificial heart valves; intravascular coils, filters or stents; vascular clips or wires; neurological implants (neurotransmitters or biostimulators); metal pins, plates, rods or screws
• Cochlear or other ear implants
• Presence of metal fragments or foreign objects in the eyes, skin or body, including; metallic fragments near the eyes or spinal cord;
• Any other form of implant (excluding dental fillings)

Study & Design

• Study Type: Observational
• Study Design: Not specified