K Study of magnetic resonance imaging (MRI) for breast screening

Phase 3

Completed

• Conditions: Cancer; Topic: National Cancer Research Network; Subtopic: Breast Cancer; Disease: Breast; Breast Cancer

• Registration Number: ISRCTN30587563
• Lead Sponsor: Medical Research Council (MRC) (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-06-18
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 900

Inclusion Criteria

Group 1:
1. Women aged 35 - 49 years
2. Tested BRCA1 or BRCA2 carriers
3. Known mutation in first degree relative
4. Family history of breast and ovarian cancer (four or more relatives)

Group 2:
1. Women aged 25 - 49 years
2. Tested p53 carriers
3. Known mutation in a first degree relative
4. Family history consistent with Li Frameni syndrome

Exclusion Criteria

1. Previous breast cancer (including ductal carcinoma in situ [DCIS])
2. Terminal illness, or life expectancy of less than 5 years
3. Pregnancy or breast-feeding (recruitment suspended until breast-feeding has finished)
4. Current chemotherapy (recruitment suspended until 6 months after treatment ceases; exclusion 2, above, still applies)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Annual MRI and x-ray breast examination

Secondary Outcome Measures

Name	Time	Method
ot provided at time of registration