To Compare the Efficacy of Intralesional Saline Versus 35% Trichloracetic Acid (TCA) Peel in the Treatment of Atrophic Acne Scars

Phase 2

Completed

• Conditions: Atrophic Acne Scar; Atrophic Acne Scarring

• Registration Number: NCT06789874
• Lead Sponsor: Sheikh Zayed Medical College

Brief Summary

This study aimed to compare the efficacy of intradermal normal saline versus trichloroacetic acid (TCA) in treating atrophic acne scars. Atrophic acne scars are a common and disfiguring complication, with limited research on the use of normal saline.

Detailed Description

Acne vulgaris is a common skin problem affecting adolescents and adults. It is the eighth most common skin disease globally, having a prevalence ranging from 35%-85%, with notable variations across different regions and age groups.A randomized controlled trial was conducted at the Dermatology Department, Sheikh Zayed Hospital, Rahim Yar Khan, from 1st April 2023 to 31st October 2023. 126 patients were enrolled. Scar grading was based on Goodman and Baron's Qualitative Scar Classification. The Observer Scar Assessment Scale (OSAS) was used by dermatologists. Patients rated their acne scars using the Visual Disease Severity Scale. Photographs were taken for comparison. Efficacy was defined as ≥50% improvement in the OSAS.

Study Timeline

• Study Start: 2023-04-01
• Primary Completion: 2023-06-30
• Study Completion: 2023-10-31
• Status Verified: 2025-01
• Study First Submitted: 2025-01-11
• Study First Submitted QC: 2025-01-16
• Last Update Submitted: 2025-01-16
• Study First Posted: 2025-01-23
• Last Update Posted: 2025-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

• Age: 13-50 years
• Clinically diagnosed patients of atrophic acne scars on face
• duration of more than 6 months
• no history of any procedural intervention in past 3 months

Exclusion Criteria

• history of keloid, active acne, local infection, skin allergies, hypertrophic scarring, photosensitivity, or history of any comorbidities
• history of use of oral isotretinoin, OCPs, steroids or immunosuppressants
• pregnant or lactating females

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Observer Scar Assessment Scale	clinical assessment will be done monthly for 6 months	efficacy was labelled as improvement on observer scar assessment scale by \>50% compared to baseline. Patient's satisfaction was recorded as 'not satisfied' (VAS score of 1-5), 'Satisfied' (VAS score of 6-7), and 'very satisfied' (Vas score of 8-10)

Trial Locations

Locations (1)

Sheikh Zayed Medical College/Hospital; 🇵🇰 Rahimyarkhan, Punjab, Pakistan