Comparing the Efficacy of Intralesional Saline Versus 35% Trichloracetic Acid (TCA) Peel in the Treatment of Atrophic Acne Scars
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Sheikh Zayed Medical College
- Enrollment
- 126
- Locations
- 2
- Primary Endpoint
- Observer Scar Assessment Scale
Study Overview
Brief Summary
This study aimed to compare the efficacy of intradermal normal saline versus trichloroacetic acid (TCA) in treating atrophic acne scars. Atrophic acne scars are a common and disfiguring complication, with limited research on the use of normal saline.
Detailed Description
Acne vulgaris is a common skin problem affecting adolescents and adults. It is the eighth most common skin disease globally, having a prevalence ranging from 35%-85%, with notable variations across different regions and age groups.A randomized controlled trial was conducted at the Dermatology Department, Sheikh Zayed Hospital, Rahim Yar Khan, from 1st April 2023 to 31st October 2023. 126 patients were enrolled. Scar grading was based on Goodman and Baron's Qualitative Scar Classification. The Observer Scar Assessment Scale (OSAS) was used by dermatologists. Patients rated their acne scars using the Visual Disease Severity Scale. Photographs were taken for comparison. Efficacy was defined as ≥50% improvement in the OSAS.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 16 Years to 40 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age: 13-50 years
- •Clinically diagnosed patients of atrophic acne scars on face
- •duration of more than 6 months
- •no history of any procedural intervention in past 3 months
Exclusion Criteria
- •history of keloid, active acne, local infection, skin allergies, hypertrophic scarring, photosensitivity, or history of any comorbidities
- •history of use of oral isotretinoin, OCPs, steroids or immunosuppressants
- •pregnant or lactating females
Arms & Interventions
Intralesional Saline for acne scars (Group A)
Intralesional Saline 5 to 10ml injected in the sacrs fortnightly for 3 months
Intervention: Intralesional Saline (Procedure)
Topical Trichloracetic acid for acne scars(Group B)
35% trichloroacetic acid peel was applied to scars monthly for 3 months
Intervention: 35% trichloracetic acid peel (Procedure)
Outcomes
Primary Outcomes
Observer Scar Assessment Scale
Time Frame: clinical assessment will be done monthly for 6 months
efficacy was labelled as improvement on observer scar assessment scale by \>50% compared to baseline. Patient's satisfaction was recorded as 'not satisfied' (VAS score of 1-5), 'Satisfied' (VAS score of 6-7), and 'very satisfied' (Vas score of 8-10)
Secondary Outcomes
No secondary outcomes reported
Investigators
Kainat usman
Post Graduate Resident in Dermatology
Sheikh Zayed Medical College