Prospective combined validation of an algorithmic calculated mean systemic filling pressure with transpulmonary pressure measurements during thoracic drainage and 3D TOE measured hemodynamic parameters.
Completed
- Conditions
- Circulatory failure10019280
- Registration Number
- NL-OMON47962
- Lead Sponsor
- Catharina-ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
- 18yrs or older
- SIgned informed consent
- Elective coronary artery bypass surgery
- Postoperative mechnically ventilated admitted to the PACU
Exclusion Criteria
- Withdrawal informed consent
- History of pneumonectomy of lobectomy
- Mechnical support of circulation
- COPD Gold 3 or 4
- Contra-indications for esophageal balloon: esophageal tumors, ulcerations,
diverticulitis, varices bleeding, recent esophageal surgery, sinusitis,
epistaxis, recent nasopharyngeal surgery.
- Complications during surgery
- Postoperative bleeding >50mL/15 minutes after admission to PACU
- No thoracic drain in pleura
- Postoperative pneumothorax
- Participation in other research studies/trials
- Elevated intra-abdominal surgery (>12 mmHg)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Endpoint 1:<br /><br>1. PmsARM and PmsINSP give a reliable reflection of volume state.<br /><br>2. A linear trend or correlation can be observed when comparing PmsALG with<br /><br>PmsARM and PmsINSP.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Endpoint 2:<br /><br>1. The pressure difference of Pes differs <5cm H2O compared to the peripheral<br /><br>pleural pressure measured<br /><br>2. The pressure difference of Per changes linear with the change in pleural<br /><br>pressure during different negative drainage pressures.<br /><br><br /><br>Endpoint 3:<br /><br>1. Cardiac parameters measured with perioperative 3D TOE change <10% in<br /><br>comparison to PiCCO and carotid artery measurement. </p><br>