Vibration Mediated Dilation and Flow Mediated Dilation in Human Circulatory System
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Istanbul University
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- Brachial Artery Diameter
Study Overview
Brief Summary
Application of vibration has been previously shown to affect tissue perfusion and utilized in different branches of medicine. Little is known about the acute impact of vibration application on peripheral artery hemodynamics. In this study, investigators intend to assess:
- vibration induced hemodynamic changes in brachial artery in non-diabetic patients and compare the characteristics of these alterations with flow mediated dilation mediated changes in same cohort.
- compare the characteristics of vibration mediated hemodynamic alterations in diabetic and non-diabetic subgroups.
Detailed Description
Background and Rationale:
Vibration application has been previously shown to affect tissue perfusion and utilized in different branches of medicine. However, previous studies have mainly focused on the impact of vibration on skin perfusion or vibration with active muscle contractions, therefore couldn't truly demonstrate acute impact of local vibration application on peripheral arteries. In addition to that, as a population that is prone to develop vascular problems, it is not known whether diabetic patients have comparable response to vibration application with non-diabetic population.
Objectives:
In this study, investigators aim to demonstrate and compare hemodynamic alterations in brachial artery with paired measurements pre- and post- vibration application and compare the characteristics of these changes with those of flow-mediated dilation in a non-diabetic cohort. Additionally, differences and similarities in vascular hemodynamic response to vibration in diabetic and non-diabetic subgroups are intended to be elucidated.
Methods:
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Sinus Rhythm in ECG
- •Ejection Fraction > %35
- •Informed Consent
Exclusion Criteria
- •Unstabile angina
- •Certain or suspected subclavian artery or brachial artery atherosclerotic disease (assessed with USG)
- •Heart failure ( New York Heart Association III - IV)
- •Atrial fibrillation or frequent extrasystoles in ECG.
Outcomes
Primary Outcomes
Brachial Artery Diameter
Time Frame: Up to 10 minutes after vibration application initiation
vessel diameter in millimeters
Brachial Artery Mean Flow Velocity
Time Frame: Up to 10 minutes after vibration application initiation
Mean flow velocity ( cm/sec) measured with Doppler
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr. Murat Sezer
Professor, MD
Istanbul University