Evaluation of two preventive schemes of dental extraction with amoxicillin in patients with rheumatoid arthritis treated with tumor necrosis factor-alpha inhibitors (anti-TNF-?) and methotrexate
- Conditions
- Rheumatoid arthritis, Inflammation, Focal Infection DentalC05.550.114.154C01.539.392.433C23.550.470
- Registration Number
- RBR-3kzp25
- Lead Sponsor
- niversidade Federal do Ceará
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Healthy volunteers and subjects with rheumatoid arthritis who make use of inhibitors of TNF-alpha and methotrexate.Participants with aged 18 to 75 years.
Patients that signed the IC (Informed Consent)and requiring simple extractions, exhibiting in blood tests (INR- international normalized ratio less than 2.5 platelet count above the 30.000; Count leukocytes above the 2.000 per mm³ and fasting glucose lower than 126 mg/dL). This study aims to enroll about 72 patients.
Patients that used antibiotics in the last 15 days. Patients allergic to Amoxicillin (experimental group).Patients with dental infection(periodontal abscess or periapical abscess).Patients with pre-existing infection. Patients that used additional immunosuppressive medication and patients who not attended the scheduled follow and/or do not follow the instructions of this study.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method