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Clinical Trials/NCT05263115
NCT05263115
Completed
N/A

An Individualized Stair Climbing Program Versus Traditional Resistance Exercise: Effects on Strength, Power, Functional Performance and Cognition in Older Adults

KU Leuven1 site in 1 country46 target enrollmentFebruary 11, 2022

Overview

Phase
N/A
Intervention
Not specified
Conditions
Exercise Training
Sponsor
KU Leuven
Enrollment
46
Locations
1
Primary Endpoint
F-V profile
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

Current evidence suggests resistance exercise as the primary therapeutic strategy to prevent age-related functional decline. The National Strength and Conditioning Association recently stated that a properly designed resistance exercise program should include power exercises performed at higher velocities in concentric movements with moderate intensities. We should be aware that not all older adults are easily motivated to train in unfamiliar gym-based settings with high subscription fees. Therefore, implementation of traditional gym-based resistance exercise at a large scale has been found to be difficult. Interestingly, we have previously shown that the use of high external loads, which implies the need for specific facility memberships, is not necessary to induce neuromuscular gains. This provides strong support for home-based training intervention strategies. Stair climbing or stepping-based exercise constitute a promising avenue to ameliorate the cost-effectiveness and implementation potential of resistance exercise in older adults. Such exercises can induce muscular activation levels similar to high-load resistance exercise and result in similar or even better gains in muscle mass, strength and power compared to slow-speed resistance exercise when properly designed. However, the (neuro)-muscular effects of stair climbing exercise have never been compared to the more optimal power-oriented resistance exercise, which is the primary aim of this study. The secondary aim of this study is to examine if stair climbing exercise also has beneficial effects on cognition.

Registry
clinicaltrials.gov
Start Date
February 11, 2022
End Date
July 30, 2022
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
KU Leuven
Responsible Party
Principal Investigator
Principal Investigator

Evelien Van Roie

Principal Investigator

KU Leuven

Eligibility Criteria

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Unstable cardiovascular disease
  • Neurological disorders
  • Cognitive malfunctioning (MoCA \< 24)
  • Low level of physical function (SPPB \< 7)
  • Acute infections/fever
  • Severe musculoskeletal problems
  • Systematic engagement in (resistance) exercise in the 12 months prior to participation

Outcomes

Primary Outcomes

F-V profile

Time Frame: Change from baseline in F-v profile at 12 weeks

Force-velocity profiling is carried out unilaterally (dominant leg) on the pneumatic leg press device (Leg Press CC, HUR, Kokkola, Finland). The test protocol consists of a maximal isometric test (knee joint angle = 85°, hip angle = 55°; 3 attempts of 3s), followed by explosive concentric leg extensions at gradually increasing loads (unloaded, 15%, 30%, 45%, 60%, 75% of the maximal isometric force, 2-3 attempts per load, and additional single repetitions until one-repetition maximum is reached). Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced adaptations. F0 (maximal force), v0 (maximal velocity), a (the equation's slope), Pmax (maximal power) and the corresponding v and F at Pmax are used for the analyses.

Secondary Outcomes

  • Gait speed(Change from baseline in gait speed at 12 weeks)
  • 5-repetition sit-to-stand power(Change from baseline in sit-to-stand performance at 12 weeks)
  • Countermovement jump height(Change from baseline in countermovement jump height at 12 weeks.)
  • 5-repetition sit-to-stand time(Change from baseline in sit-to-stand performance at 12 weeks)
  • Stair ascent power(Change from baseline in stair climbing performance at 12 weeks.)
  • Digit Span Test score(Change from baseline in Digit Span Test score at 12 weeks.)
  • Stroop Test number of words(Change from baseline in Stroop Test at 12 weeks.)
  • Stair ascent time(Change from baseline in stair climbing performance at 12 weeks.)
  • Trail Making Test Time(Change from baseline in Trail Making Test at 12 weeks.)
  • MoCA test score(Change from baseline in Montrial Cognitive Assessment test score at 12 weeks.)

Study Sites (1)

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