Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Morphine consumption in PACU and in hospitalisation room
研究概览
简要总结
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.
We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.
详细描述
Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •total hip arthroplasty
排除标准
- •pre operative opioid administration
研究组 & 干预措施
A
Ketamine pre and per operative, and morphine postoperative
干预措施: Ketamine-Morphine (Drug)
B
NaCl pre and per operative, and morphine postoperative
干预措施: Morphine (Drug)
C
Ketamine and morphine postoperative
干预措施: Postoperative PCA of Ketamine and morphine (Drug)
结局指标
主要结局
Morphine consumption in PACU and in hospitalisation room
时间窗: at 24 and 48 hours
次要结局
- Postoperative Visual Analogic Score of pain(in Recovery Room, at 24 and 48 hours, in the ward)
- Postoperative Measure of mechanical hyperalgesia by Von Frey filament device(24 and 48 hours in the ward)
- Postoperative measure Ketamine and Nor-Ketamine blood levels(at 24 and 48 hours in the ward)