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Clinical Trials/NCT04702607
NCT04702607CompletedNot Applicable

Pilot Study to Assess Lung Function Using Perfusion Blood Volume Dual Energy CT and 4DCT Derived Lung Ventilation Imaging

Abramson Cancer Center at Penn Medicine1 site in 1 country40 target enrollmentStarted: January 2, 2021Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
40
Locations
1
Primary Endpoint
evaluate the reproducibility of PBV DECT imaging and 4DCT derived lung ventilation for evaluating lung function
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The basic premise of this pilot study is to enroll 40 patients over 3 years who have Stage II, III, or IV non-small cell lung cancer and are planned for definitive treatment with concurrent chemoradiation where a contrast enhanced 4DCT is planned.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

evaluate the reproducibility of PBV DECT imaging and 4DCT derived lung ventilation for evaluating lung function

Time Frame: 3 years

correlate changes of PBV DECT and 4DCT lung function images seen at ~6 months with radiation dose and with patient reported outcome quality of life

Time Frame: 3 years

Secondary Outcomes

  • • To propose a novel biologic (i.e. functional) dose volume algorithm to reduce PBV and 4DCT lung function changes(3 years)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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