A randomized controlled double-blinded trial comparing the effect of on demand rocuronium boluses vs continuous infusion on rating of surgical and anesthesia conditions and need for reversal in patients undergoing thoracolaparoscopic esophagectomy.
Completed
- Conditions
- Surgical conditions during esophagectomy10017998
- Registration Number
- NL-OMON40986
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
All patients for laparothoracoscopic oesophagus cardia resection (Ivor Lewis or McKeown procedure)
Exclusion Criteria
Age < 18, or pregnancy, known allergies for aminosteroid-type muscle relaxants or sugammadex.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p> Rating of surgical conditions (SRS) during the abdominal phase of the<br /><br>operation.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Rating of SRS during thoracic phase of the operation. Number of on demand<br /><br>boluses infused, indication of on demand bolus administration,<br /><br>- Rating of anesthesia conditions including: peak and mean respiratory<br /><br>pressure, incidence peak insufflation pressure >35 mmHg. Depth of NBM at the<br /><br>end of surgery. Time until spontaneous breathing, time until extubation.<br /><br>Peroperative cardiac and respiratory incidents.<br /><br>- Cost analysis: amount of rocuronium used (mg); Dose of sugammadex needed<br /><br>(mg), time to reversal, duration of surgery, hypothetical need for need for<br /><br>post-operative ventilation (%).</p><br>