NCT03979625已完成不适用
Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation
Central Hospital, Nancy, France0 个研究点目标入组 39 人开始时间: 2016年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 39
- 主要终点
- Death
研究概览
简要总结
Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock. Similarly to postcardiac surgery patients, heparin-induced thrombocytopenia (HIT) could represent the causative underlying mechanism. However, the epidemiology as well as related mortality regarding HIT and VA-ECMO remains largely unknown. The investigators aimed to define the prevalence and associated 90-day mortality of HIT diagnosed under VA-ECMO.This retrospective study included patients under VA-ECMO from 20 French centers between 2012 and 2016.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Patient hospitalized in intensive care for a cardiovascular failure requiring the setting up of an ECMO-VA
- •ECMO-VA duration ≥ 3 days
- •HIT confirmed by immunological tests
- •Patient affiliated to a Social Security scheme
排除标准
- •Known antecedent of TIH prior to cannulation
- •Pregnant woman
- •ECMO-VA following cardiopulmonary arrest or septic shock
结局指标
主要结局
Death
时间窗: 90 days after inclusion
次要结局
未报告次要终点
研究者
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