跳至主要内容
临床试验/NCT03979625
NCT03979625已完成不适用

Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation

Central Hospital, Nancy, France0 个研究点目标入组 39 人开始时间: 2016年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
39
主要终点
Death

研究概览

简要总结

Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock. Similarly to postcardiac surgery patients, heparin-induced thrombocytopenia (HIT) could represent the causative underlying mechanism. However, the epidemiology as well as related mortality regarding HIT and VA-ECMO remains largely unknown. The investigators aimed to define the prevalence and associated 90-day mortality of HIT diagnosed under VA-ECMO.This retrospective study included patients under VA-ECMO from 20 French centers between 2012 and 2016.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age ≥ 18 years
  • Patient hospitalized in intensive care for a cardiovascular failure requiring the setting up of an ECMO-VA
  • ECMO-VA duration ≥ 3 days
  • HIT confirmed by immunological tests
  • Patient affiliated to a Social Security scheme

排除标准

  • Known antecedent of TIH prior to cannulation
  • Pregnant woman
  • ECMO-VA following cardiopulmonary arrest or septic shock

结局指标

主要结局

Death

时间窗: 90 days after inclusion

次要结局

未报告次要终点

研究者

发起方
Central Hospital, Nancy, France
申办方类型
Other
责任方
Sponsor

相似试验