Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation
Completed
- Conditions
- Heparin-induced Thrombocytopenia
- Registration Number
- NCT03979625
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock. Similarly to postcardiac surgery patients, heparin-induced thrombocytopenia (HIT) could represent the causative underlying mechanism. However, the epidemiology as well as related mortality regarding HIT and VA-ECMO remains largely unknown. The investigators aimed to define the prevalence and associated 90-day mortality of HIT diagnosed under VA-ECMO.This retrospective study included patients under VA-ECMO from 20 French centers between 2012 and 2016.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 39
Inclusion Criteria
- Age ≥ 18 years
- Patient hospitalized in intensive care for a cardiovascular failure requiring the setting up of an ECMO-VA
- ECMO-VA duration ≥ 3 days
- HIT confirmed by immunological tests
- Patient affiliated to a Social Security scheme
Exclusion Criteria
- Known antecedent of TIH prior to cannulation
- Pregnant woman
- ECMO-VA following cardiopulmonary arrest or septic shock
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Death 90 days after inclusion
- Secondary Outcome Measures
Name Time Method