Intestinal Dysmotility: Effect of Colonic Load
- Conditions
- Healthy Volunteers
- Interventions
- Other: Colonic gas loadOther: Sham load
- Registration Number
- NCT05046743
- Brief Summary
Abnormal motility patterns in the jejunum can be detected in patients with prominent colonic distension, and it is not clear whether these abnormalities reflect a primary jejunal dysfunction or are due to a reflex distortion. The aim of the study is to determine the effect of colonic filling on jejunal postprandial motility using high-resolution manometry.
Healthy subjects will be studied following a controlled, parallel, randomized, single-blind experimental design. On the study day, nutrients will be continuously infused in the proximal jejunum (2 Kcal/min) during a 2-h period to induce a steady-state postprandial motor pattern. Jejunal motility will be concomitantly recorded using a water-perfused, high-resolution manometry catheter. After 1 hour of postprandial recording (basal period), a gas mixture will be infused during 7.5 minutes via a rectal tube (720 mL or sham infusion), and jejunal motility will be recorded for another hour.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- No digestive symptoms
- Organic diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Colonic gas load Colonic gas load - Sham Sham load -
- Primary Outcome Measures
Name Time Method Small bowel contractility 10 minutes Number of contractions
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain