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Clinical Trials/NCT06661031
NCT06661031
Enrolling By Invitation
Not Applicable

Developing a Telehealth + mHealth Cannabis Use Intervention for Young Adults

Boston Children's Hospital1 site in 1 country65 target enrollmentDecember 10, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cannabis Use Disorder
Sponsor
Boston Children's Hospital
Enrollment
65
Locations
1
Primary Endpoint
Intervention completion
Status
Enrolling By Invitation
Last Updated
4 months ago

Overview

Brief Summary

The goal of this clinical trial is to determine 1) feasibility of the MOMENT-V intervention for cannabis use disorder in young adults, 2) feasibility of conducting the trial remotely, and 3) whether the MOMENT-V intervention reduces cannabis use frequency and problems. Researchers will compare the MOMENT-V intervention to usual care enhanced by a counselor meeting.

Participants will either meet with a counselor two times and use an app on their phone for two weeks, or meet with a counselor briefly one time. All participants will be asked to complete electronic surveys, interviews with a research assistant, and saliva drug testing at home over three months.

Registry
clinicaltrials.gov
Start Date
December 10, 2024
End Date
May 1, 2027
Last Updated
4 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Lydia Shrier

Research Director, Division of Adolescent/Young Adult Medicine

Boston Children's Hospital

Eligibility Criteria

Inclusion Criteria

  • Primary care patient of the Boston Children's Hospital Adolescent/Young Adult Medicine Practice
  • Participation in MOMENT-V open pilot
  • Ownership of a smartphone
  • Availability for the 2-week study duration

Exclusion Criteria

  • Inability/Unwillingness to provide contact information
  • Current pregnancy or parenting
  • For the pilot RCT
  • Inclusion Criteria:
  • Primary care patient of the Boston Children's Hospital Adolescent/Young Adult Medicine Practice or Martha Eliot Health Center Adolescent Clinic
  • 18 to 26 years old
  • Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score of ≥12
  • Recreational cannabis use on \>3 days/week, on average, in the past 30 days
  • Ownership of a smartphone that is PIN- or password-protected
  • Ability to read and speak English

Outcomes

Primary Outcomes

Intervention completion

Time Frame: At week 3 (Upon completion of 2-week EMI period)

\[Aim 1\] Percent of participants assigned to the intervention arm completing the intervention (defined as both MET sessions and any EMI surveys). Benchmark: ≥80%

EMI engagement

Time Frame: In weeks 1-3 (during 2-week EMI period)

\[Aim 1\] Percent of days on which participant responded to at least one survey during the 14 days of EMI. Benchmark: Median of ≥80% across intervention participants

Acceptability: Overall satisfaction

Time Frame: At 6-month timepoint

\[Aim 1\] Satisfaction with intervention measured on the Client Satisfaction Questionnaire-8, an 8-item 4-point scale on which scores range from 8-32, with higher scores indicating greater satisfaction. Benchmark: ≥80% of participants with a scale score ≥24 (mean item score of ≥3 out 4)

Acceptability: Components

Time Frame: At week 0, week 1, and week 3

\[Aim 1\] Measure of acceptability (usability, likability, perceived effect, burden) for each intervention component (2 MET sessions and EMI). Components assessed with an 11- or 12-item 5-point Likert-type scales (1, Strongly Disagree to 5, Strongly Agree) developed for the study. Higher scores indicate greater acceptability. Benchmark for each scale: ≥80% of participants with mean item score ≥4 out of 5

Screening

Time Frame: During recruitment (upon completion of eligibility survey: pre-enrollment, pre-Baseline)

\[Aim 2\] Number of patients self-screening per month. Benchmark: ≥13 per month

Eligibility

Time Frame: During recruitment (upon completion of eligibility survey: pre-enrollment, pre-Baseline)

\[Aim 2\] Number of patients eligible per month. Benchmark: ≥6 per month

Enrollment

Time Frame: Upon enrollment

\[Aim 2\] Number of patients enrolled per month. Benchmark: ≥3 per month

Retention in trial

Time Frame: At 3-week timepoint, 3-month timepoint, 6-month timepoint

\[Aim 2\] Percent of participants retained at each assessment time point (3 weeks, 3 months, 6 months, by assigned condition. Benchmark: ≥80% at each time point

Days of cannabis use

Time Frame: At Baseline, 3-week timepoint, 3-month timepoint, 6-month timepoint

\[Aim 3\] Number of cannabis use days measured on Timeline Follow-Back (TLFB) calendar

Times of cannabis use

Time Frame: At Baseline, 3-week timepoint, 3-month timepoint, 6-month timepoint

\[Aim 3\] Number of cannabis use times measured on TLFB calendar

Negative consequences of cannabis use

Time Frame: At Baseline, 3-month timepoint, 6-month timepoint

\[Aim 3\] Number of negative consequences (problems) measured on the 19-item Marijuana Problems Scale

Secondary Outcomes

  • Therapeutic alliance(At week 1)
  • MET counselor adherence to MI principles(At week 0 and week 1)
  • Duration of study activities(All timepoints, upon completion of each timepoint (Baseline, week 0, week 1, weeks 1-3 [two-week EMI period], 3-weeks, 3-months, 6-months))
  • Cannabis use disorder (CUD) symptoms(At Baseline, 3-month timepoint, 6-month timepoint)
  • Amount of THC used(At Baseline, 3-week timepoint, 3-month timepoint, 6-month timepoint)
  • Motivation to change cannabis use(At Baseline, week 0, week 1, 3-months, 6-months)
  • Psychological distress(At Baseline, 3-month timepoint, 6-month timepoint)
  • Cognitive function(At Baseline, 3-month timepoint, 6-month timepoint)
  • Quality of life(At Baseline, 3-month timepoint, 6-month timepoint)

Study Sites (1)

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