Prevalence Of Uveitis in Pediatric Autoimmune Rheumatic Diseases (AIRD) and Autoinflammatory Diseases.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- 1. Prevalence of uveitis in pediatric rheumatic and autoinflammatory disease patients.
研究概览
简要总结
Uveitis is a known complication in pediatric autoimmune and autoinflammatory diseases, particularly in Juvenile Idiopathic Arthritis (JIA). Uveitis has been reported to contribute to 25% of cases of blindness in the developing world and about 3-10% in the Western world. Among uveitis patients, children comprise around 2.2-13.8% of the cases. Over a fifth of pediatric uveitis cases present with moderate/severe visual impairment, especially in older age or with prior oral corticosteroid therapy. Given the significant morbidity associated with uveitis, early screening and identification of uveitis are crucial in pediatric patients.
To determine the prevalence and types of uveitis in children aged 2-16 years diagnosed with autoimmune rheumatic diseases (AIRD) and autoinflammatory diseases.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 2.00 Year(s) 至 16.00 Year(s)（—）
- 性别
- All
入选标准
- •Children aged 2-16 years diagnosed with any autoimmune rheumatic disease (Juvenile Idiopathic Arthritis (JIA), Autoinflammatory syndromes).
排除标准
- •1.Children with infectious diseases.
- •2.Children with significant comorbidities unrelated to rheumatic conditions.
- •3.Children with poor vision due to other causes.
结局指标
主要结局
1. Prevalence of uveitis in pediatric rheumatic and autoinflammatory disease patients.
时间窗: 3 Months, 6 Months, 12 Months,18 Months, 24 Months
2. Types of uveitis (anterior, intermediate, posterior, or panuveitis) in subsets of pediatric rheumatic diseases.
时间窗: 3 Months, 6 Months, 12 Months,18 Months, 24 Months
次要结局
- 1.Association between levels of inflammatory markers (e.g., ESR, CRP) and the occurrence and severity of uveitis.(2.Correlation between disease activity scores in rheumatic diseases and uveitis occurrence.)
研究者
DrShabtab Nasir
L V Prasad Eye Institute