An assessment of nutritional deficiencies in patients with primary antibody deficiency and bronchiectasis.

Withdrawn

• Conditions: bronchiectasieen; defects of immune system; immune deficiency; 10021460

• Registration Number: NL-OMON46112
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

- Diagnosis of primary antibody deficiency
- Bronchiectasis diagnosed by chest CT scanning
- Informed consent

Exclusion Criteria

- Inability to give informed consent
- Active infection/ exacerbation requiring antibiotic treatment in the 2 weeks prior to study inclusion

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>7.1.1 Main study parameter/endpoint<br /><br>- Dietary intake of micro- and micronutrients<br /><br>- Body composition as estimated with bioelectrical impedance analysis<br /><br>- Serum levels of micro- and macro nutrients </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>7.1.2 Secondary study parameters/endpoints<br /><br>- demographic information,<br /><br>- height, weight,<br /><br>- type of PAD,<br /><br>- extent of bronchiectasis as measured by BRICS score,<br /><br>- lung function (FEV1/ FVC)<br /><br>- exacerbation frequency in year prior to study inclusion<br /><br>- markers of systemic inflammation (CRP/ WBC count)<br /><br>- sputum microbiology<br /><br>- Bronchiectasis severity scores (BSI and FACED scores)<br /><br>- QoL and symptoms as measured by LRTI-VAS, CVID-QoL and QOL-B</p><br>