Vonafexor ALPort Syndrome Efficacy & Safety TRIAl-1 (ALPESTRIA-1)

Phase 2

Recruiting

Brief Summary: This study is a proof-of-concept trial of vonafexor safety, its effects on kidney function in subjects with at risk of progression Alport syndrome.

Detailed Description: This is a multicenter study and several clinical sites and countries will be involved.

This single arm, fixed dose escalation, open-label, non-randomized study will evaluate three dose levels of vonafexor on safety, tolerability and their effect on kidney function and renal biomarkers in 20 patients with AS at risk of progression.

The total duration of study for a participant will be up to 40 weeks and include a screening period, a treatment period of 24 weeks and a follow-up period of 12 weeks.

Recruitment & Eligibility

Inclusion Criteria

Signed informed consent (also for legal representatives, as applicable in the US for under eighteen patients).
Has confirmed diagnosis of Alport syndrome: clinical diagnosis (haematuria, family history, hearing loss, ocular change) OR a kidney biopsy showing glomerular basement membrane abnormalities consistent with AS, AND Genetic confirmation of AS.
Has eGFR between ≥ 30 and < 90 ml/min/1.73m2.
Has increased albuminuria criteria i.e. UACR ≥ 300 mg/g.
If on an angiotensin converting enzyme inhibitor (ACEi) and/or angiotensin receptor blocker (ARB), should be on a stable well tolerated treatment during at least the 60 days prior D1.
If on Sodium-Glucose Transport Protein 2 (SGLT2), should be on stable well tolerated treatment with SGLT2 during at least 60 days prior D1.
If patient has a history of arterial hypertension, should be on stable anti-hypertensive therapy for at least 60 days prior to D1 and deemed controlled by the investigator at screening and D1.
Sexually active female subjects of childbearing potential and sexually mature male subjects must use two acceptable effective methods of contraception for the entire duration of the study and for at least 6 weeks after last dose.
Has negative results for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, and human immunodeficiency virus (HIV).
Is able to understand all study procedures in the informed consent form (ICF) and willing to comply with all aspects of the protocol.

Exclusion Criteria

Is an employee of a site, clinical research organization, vendor, or sponsor involved with this study.
Is pregnant or breastfeeding.
Has participated in any investigational drug study within 60 days prior to D1.
Any clinically significant illness within 30 days before D1 or surgical or medical condition (other than Alport syndrome) that could interfere with the subject's study compliance; confound the study results; impact subject safety.
Any history of active malignancy within the last 1 year before D1.
Any other condition or circumstance that, in the opinion of the investigator, may make the subject unlikely to complete the study or comply with study procedures and requirements, or may pose a risk to the subject's safety and well-being.
Has a history of an allergic condition that required the prescription of an emergency epinephrine injection (such as the EpiPen® Auto-Injector).
Any prohibited co-medications within 30 days prior D1.
Has ALT or AST above near normal (>1.5×ULN) at baseline.
Are at high risk for atherosclerotic cardiovascular disease (ASCVD) risk, with an LDL-C level > 160 mg/dL (4.15 mmol/L) and subjects at intermediate risk for ASCVD risk, with a LDL-C level > 190 mg/dL (4.91 mmol/L).
Has moderate or severe hepatic impairment (Child-Pugh score B or C).
Is taking CYP3A4/5 inhibitors or inducers.

Arm && Interventions

Group	Intervention	Description
Single arm fixed dose escalation	Vonafexor	This is a single arm fixed dose escalation with three dose levels of vonafexor, all QD.

Primary Outcome Measures

Name	Time	Method
Number of Treatment-Emergent Adverse Event (TEAE)	From first dose of treatment until 2 weeks after last dose of treatment, i.e assessed up to 26 weeks	To assess the safety and tolerability of vonafexor

Secondary Outcome Measures

Name	Time	Method
Vonafexor plasma concentrations	During on-treatment period, assessed up to 24 weeks	To determine vonafexor plasma concentrations levels
Change in eGFR	During on-treatment (assessed up to 24 weeks) and off-treatment periods (assessed up to 36 weeks) compared to baseline	To determine the on with the off-treatment effect of three dose levels of vonafexor on renal function

Locations (17): Dr Eric Wallace - University of Alabama
🇺🇸
Birmingham, Alabama, United States
Dr Anjay Rastogi - UCLA Health, David Geffen School of Medicine
🇺🇸
Los Angeles, California, United States
Dr Arnold Silva - Boise Kidney & Hypertension
🇺🇸
Boise, Idaho, United States
Dr Suneel Udani - NANI Research
🇺🇸
Hinsdale, Illinois, United States
Dr Tingting Li - Washington University
🇺🇸
St. Louis, Missouri, United States
Dr Andrew Bomback - Columbia University Medical Center
🇺🇸
New York, New York, United States
Dr James Simon - Cleveland Clinic Foundation
🇺🇸
Cleveland, Ohio, United States
Dr Ankit Mehta - Renal Disease Research Institute
🇺🇸
Dallas, Texas, United States
Pr Claire Rigothier - CHU De Bordeaux
🇫🇷
Bordeaux, France
Dr Thomas Robert - Hôpital de la Conception
🇫🇷
Marseille, France
Dr Moglie Le Quintrec - Hopital Lapeyronie
🇫🇷
Montpellier, France
Pr. Bertrand Knebelmann - Necker Enfants Malades
🇫🇷
Paris, France
Charite Universitatsmedizin Berlin
🇩🇪
Berlin, Germany
University Medicine Goettingen
🇩🇪
Göttingen, Germany
Fundacio Puigvert
🇪🇸
Barcelona, Spain
Hospital Virgen de la Arrixaca
🇪🇸
El Palmar, Spain
Fundacion Jimenez Diaz
🇪🇸
Madrid, Spain