NL-OMON53877招募中不适用
Improvement of laboratory diagnostics in hypothyroid patients using levothyroxine. - ANTICIPATE
Amsterdam UMC0 个研究点目标入组 500 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Hypothyroid patients
- •- Ability to provide informed consent;
- •- Ability to speak and understand Dutch or English
- •- Intake of a stable dose of levothyroxine, meaning the dosage of levothyroxine
- •must not be changed during the appointment at the outpatient clinic
- •- Diagnosis of one of these forms of hypothyroidism
- •O Patients with primary hypothyroidism: euthyroid based on TSH according to
- •O Patients with hypothyroidism after a total thyroidectomy due to thyroid
- •carcinoma (therefore athyroid): on target TSH according to physician (target
- •TSH depending on stage/severity of carcinoma)
- •O Patients using L-T4 due to therapy of Graves* disease: euthyroid based on TSH
- •according to physician (TSH cannot be suppressed, namely TSH within reference
- •interval of 0,5-5,0 mU/L)
- •O Patients with central hypothyroidism: euthyroid based on fT4 according to
- •physician (common is fT4 in the upper limit, reference interval is 12-22 pmol/L)
- •Healthy controls
- •- Ability to provide informed consent;
- •- Ability to speak and understand Dutch or English
- •- Consider themselves healthy
排除标准
- •Hypothyroid patients
- •- Not euthyroid according to physician
- •- Pregnant
- •- Patients using L-T4 due to the treatment of Graves* disease: if TSH is still
- •- Any of the following medication
- •o Liothyronine (Cytomel)
- •o Oral anticonceptiva
- •o Active treatment of malignancy (except DTC)
- •Healthy controls
- •- Pregnancy
- •- Any of the following medication
- •o Thyroid medication (a.o. levothyroxine, thiamazol, PTU)
- •o Amiodarone
- •o Propranolol
- •o Glucocorticoids
- •o Oral contraceptives
- •o Growth hormone
- •o Active treatment of malignancy
研究者
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