CTRI/2024/09/073918尚未招募不适用
Relation between adenosine diphosphate stimulated platelet aggregation and vascular endothelial growth factor release in branch retinal vein occlusion
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Platelet aggregation response to adenosine diphosphate in subjects of branch retinal vein occlusion.
研究概览
简要总结
A total of thirty treatment naïve subjects in the age group of 45 to 65 years having branch retinal vein occlusion will be enrolled. A thorough history will be taken and a detailed ocular examination will be done. Platelet aggregation will be evaluated by inducing the aggregation of human platelets (250× 103/μl) with adenosine diphosphate (200 μM) using the principle of light transmission aggregometry with aggregometer (Helena AggRAM). For all the subjects, VEGF-A will be estimated by Enzyme Linked Immunosorbent Assay (ELISA) with commercially available kits
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 45.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Subjects having normal platelet count, prothrombin time and activated partial thromboplastin time.
- •Subjects not on any anti-platelet-aggregating drugs, anticoagulants or non-steroidal anti-inflammatory drugs.
排除标准
- •Subjects having other ocular diseases like glaucoma, media opacity, optic nerve disorders, high refractive errors, other significant co-existing retinal diseases especially those which affect macular perfusion (e.g. diabetic retinopathy, uveitis and vasculitis) 2)Subjects having best corrected visual acuity lesser than 6/60.
结局指标
主要结局
Platelet aggregation response to adenosine diphosphate in subjects of branch retinal vein occlusion.
时间窗: 4weeks
次要结局
- 1)Serum levels of vascular endothelial growth factor-A (VEGF-A)(2)Posterior segment Optical Coherence Tomography parameters (Central foveal thickness and sub-foveal choroidal thickness) and Optical Coherence Tomography Angiography parameters (Foveal Avascular Zone, vessel density))
研究者
Dr Punita Kumari Sodhi
Maulana Azad Medical College
研究点 (1)
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