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Observational Study to Evaluate Short and Long-term Safety of the ABSORB Scaffold

Completed
Conditions
Coronary Artery Stenosis
Interventions
Device: ABSORB Scaffold
Registration Number
NCT02066623
Lead Sponsor
IHF GmbH - Institut für Herzinfarktforschung
Brief Summary

The German-Austrian ABSORB Register shall provide an analysis of acute and long-term safety as well as therapy outcomes of the ABSORB (trade mark) bioresorbable vascular scaffold system in patients suffering from coronary artery disease.

Detailed Description

The register collects prospective data regarding the quality of care of this therapy concept including specifically the following objectives:

* Documentation of all consecutive patients having been treated with the ABSORB biore-sorbable vascular scaffold system under clinical real-world conditions

* Documentation of indications, procedural results, and short and long-term outcomes

* Documentation of the technical performance of ABSORB implant procedures

* Collection of safety data, in particular documentation of hospital mortality, major non-fatal complications (especially myocardial infarction, Re-PCI (percutaneous coronary intervention) or CABG (coronary artery bypass grafting), stroke, thrombosis)

* Documentation of long-term patient safety marked by mortality and major non-fatal complications (especially myocardial infarction, Re-PCI or CABG, stroke, thrombosis) at 30 days, 6 months, 2 years and 5 years

* Gathering of health economics data (capture of direct costs, especially with view to change of medication and outpatient/inpatient hospital services, and indirect costs) pre and post ABSORB implant

* Gathering data on the quality of life pre and post ABSORB implant to document individual QoL dimensions as well as QALY (quality adjusted life year) data

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
3330
Inclusion Criteria
  • ABSORB implant scheduled
  • Age 18+
  • Patients giving consent to keep scheduled follow-ups
  • Signed informed consent
Exclusion Criteria
  • None

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Implantation of ABSORB ScaffoldABSORB ScaffoldPatients suffering from coronary artery stenosis with an indication for implantation of ABSORB scaffold
Primary Outcome Measures
NameTimeMethod
Number of serious adverse cardiac events5 years after index procedure

The following events will be evaluated:

* Death

* Myocardial infarction

* Clinically motivated target vessel revascularization

* Clinically motivated target lesion revascularization

* Composite target parameter of the aforementioned events (MACE, major adverse cardiac event) as the primary target parameter

* Stroke

* Composite target parameter of the aforementioned events including stroke as the primary target parameter (MACCE, major adverse cardiac and cerebrovascular event)

* Stent thrombosis

Secondary Outcome Measures
NameTimeMethod
Success of ABSORB implantationduring implantation of ABSORB scaffold

The following parameters will be evaluated to assess procedural outcome:

* Technical success: If the residual stenosis is less than 30% in the ABSORB covered lesion segment at the end of the procedure based on visual estimation

* Therapy success: Technical success and no periprocedural complications

* Clinical success: Therapy success and no serious adverse cardiac (and cerebrovascular) events (MACE, MACCE)

* TIMI (thrombolysis in myocardial infarction) flow pre and post implant

* Sudden occlusion of side branch in the case of bifurcation stenosis

* Optional: Quantitative coronary angiography (QCA) with index treatment: final in-scaffold and in-segment percentage diameter stenosis (%DS), reference vessel diameter

Trial Locations

Locations (81)

LKH Graz-West

🇦🇹

Graz, Austria

Ilm-Kreis-Kliniken, Arnstadt-Ilmenau

🇩🇪

Arnstadt, Germany

Zentralklinik Bad Berka

🇩🇪

Bad Berka, Germany

SLK-Kliniken, Klinikum am Plattenwald

🇩🇪

Bad Friedrichshall, Germany

Herzzentrum Bad Krozingen

🇩🇪

Bad Krozingen, Germany

Hufeland Klinikum

🇩🇪

Bad Langensalza, Germany

Kerckhoff-Klinik

🇩🇪

Bad Nauheim, Germany

Herz- und Diabeteszentrum Nordrhein-Westfalen

🇩🇪

Bad Oeynhausen, Germany

Segeberger Kliniken GmbH

🇩🇪

Bad Segeberg, Germany

Caritas-Klinik Pankow

🇩🇪

Berlin, Germany

Segeberger Kliniken

🇩🇪

Bad Segeberg, Germany

Charité - Universitätsmedizin Berlin-Campus Benjamin Franklin

🇩🇪

Berlin, Germany

Charité - Universitätsmedizin Berlin - Campus Virchow-Klinikum

🇩🇪

Berlin, Germany

Vivantes Klinikum Spandau

🇩🇪

Berlin, Germany

Vivantes-Klinikum Am Urban

🇩🇪

Berlin, Germany

Vivantes Klinikum Neukölln

🇩🇪

Berlin, Germany

Vivantesklinik im Friedrichshain

🇩🇪

Berlin, Germany

Gesundheitszentrum Bitterfeld-Wolfen

🇩🇪

Bitterfeld-Wolfen, Germany

Immanuel Klinikum Bernau

🇩🇪

Bernau, Germany

St. Josef- und Elisabeth- Hospital

🇩🇪

Bochum, Germany

Klinikum Links der Weser

🇩🇪

Bremen, Germany

Krankenhaus Buchholz

🇩🇪

Buchholz, Germany

Klinikum Coburg

🇩🇪

Coburg, Germany

Kardiovaskuläres Zentrum Darmstadt

🇩🇪

Darmstadt, Germany

Sana-Herzzentrum Cottbus

🇩🇪

Cottbus, Germany

Praxisklinik Herz und Gefässe Dresden

🇩🇪

Dresden, Germany

Werner-Forßmann-Krankenhaus

🇩🇪

Eberswalde, Germany

Kliniken Im Naturpark Altmühltal, Klinik Eichstätt

🇩🇪

Eichstätt, Germany

Alfried Krupp v. Bohlen Krankenhaus

🇩🇪

Essen, Germany

Klinikum Fulda

🇩🇪

Fulda, Germany

Universitätsklinikum Essen

🇩🇪

Essen, Germany

Universitätsklinikum Erlangen

🇩🇪

Erlangen, Germany

Universitätsklinikum Freiburg

🇩🇪

Freiburg, Germany

Main-Kinzig-Kliniken

🇩🇪

Gelnhausen, Germany

Elisabeth Krankenhaus Essen

🇩🇪

Essen, Germany

Universitätsklinikum Gießen

🇩🇪

Gießen, Germany

Universitätsklinikum Greifswald

🇩🇪

Greifswald, Germany

Universitätsklinikum Göttingen

🇩🇪

Göttingen, Germany

Asklepios Klinik Harburg

🇩🇪

Hamburg, Germany

Med. Hochschule Hannover

🇩🇪

Hannover, Germany

Asklepios Klinik St. Georg

🇩🇪

Hamburg, Germany

Universitäres Herzzentrum Eppendorf

🇩🇪

Hamburg, Germany

SLK-Kliniken Heilbronn

🇩🇪

Heilbronn, Germany

Oberhavel Kliniken-Klinik Hennigsdorf

🇩🇪

Hennigsdorf, Germany

Krankenhaus Herford

🇩🇪

Herford, Germany

Klinikum Itzehoe

🇩🇪

Itzehoe, Germany

Herz- und Gefäßzentrum Oberallgäu-Kempten

🇩🇪

Immenstadt, Germany

Herzzentrum Universitätsklinikum Köln

🇩🇪

Köln, Germany

Stiftungsklinikum Mittelrhein

🇩🇪

Koblenz, Germany

Herz- und Gefäßzentrum Oberallgäu/Kempten

🇩🇪

Kempten, Germany

Universitätsklinikum Leipzig

🇩🇪

Leipzig, Germany

Universitätsklinikum Schleswig Holstein

🇩🇪

Lübeck, Germany

Klinikum Ludwigshafen

🇩🇪

Ludwigshafen am Rhein, Germany

Klinikum Lüdenscheid

🇩🇪

Lüdenscheid, Germany

St. Marien-Hospital

🇩🇪

Lünen, Germany

Universitätsklinikum Mainz

🇩🇪

Mainz, Germany

Universitätsklinikum Mannheim

🇩🇪

Mannheim, Germany

Universitätsklinikum Magdeburg

🇩🇪

Magdeburg, Germany

Universitätsklinikum Marburg

🇩🇪

Marburg, Germany

Deutsches Herzzentrum München

🇩🇪

Munich, Germany

Isar Herz Zentrum München

🇩🇪

Munich, Germany

Klinikum der Universität München , Campus Großhadern

🇩🇪

Munich, Germany

Evangelisches Krankenhaus Mülheim

🇩🇪

Mülheim, Germany

Städtisches Klinikum München - Neuperlach

🇩🇪

Munich, Germany

Klinikum München-Bogenhausen

🇩🇪

Munich, Germany

Krankenhaus St. Franziskus Mönchengladbach

🇩🇪

Mönchengladbach, Germany

Universitätsmedizin Rostock

🇩🇪

Rostock, Germany

GPR Klinikum Rüsselsheim

🇩🇪

Rüsselsheim, Germany

Elbe Klinikum Stade

🇩🇪

Stade, Germany

St. Marien-Krankenhaus

🇩🇪

Siegen, Germany

SRH Zentralklinikum Suhl

🇩🇪

Suhl, Germany

Universitätsklinikum Ulm

🇩🇪

Ulm, Germany

St. Marienhospital

🇩🇪

Vechta, Germany

Schwarzwald-Baar Klinikum

🇩🇪

Villingen-Schwenningen, Germany

Rems-Murr-Klinik Winnenden

🇩🇪

Winnenden, Germany

Heinrich-Braun-Krankenhaus

🇩🇪

Zwickau, Germany

LKH Villach

🇦🇹

Villach, Austria

Landeskrankenhaus-Univ.Klinikum Graz

🇦🇹

Graz, Austria

A.ö. Krankenhaus der Stadt Linz

🇦🇹

Linz, Austria

Medizinische Universität Wien

🇦🇹

Vienna, Wien, Austria

Medizinische Universität Innsbruck

🇦🇹

Innsbruck, Austria

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