Cortical Representation of NGF-induced Hyperalgesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Changes in activation of the pain processing and resting state networks
研究概览
简要总结
Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain. The mechanisms of the cognitive modulation of pain and hyperalgesia are not yet understood in this group of patients. The investigators plan to use NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects to investigate the underlying neuronal mechanisms of this hyperalgesia using functional magnetic resonance imaging and resting state network analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •no acute or chronic disease
- •no acute or chronic pain
- •age: 18-60 years
- •no medication use
排除标准
- •metallic parts in the body
- •claustrophobia
- •drug or substance abuse
结局指标
主要结局
Changes in activation of the pain processing and resting state networks
时间窗: baseline to one week
Activation of the resting state network (using functional magnetic resonance imaging (fMRI) and a standard echo planar imaging (EPI) sequence) as well as acitvation of the pain processing network (using fMRI and a standard EPI sequence) in response to painful stimulation, will be measured before and after injection of NGF into the volar forearm of the participant. Particants are measured 0-4 days before injection (baseline) and then again 4-7 days after injection (to measure changes due to NGF injection).
次要结局
- Changes in pain intensity, unpleasentness and suffering ratings(baseline to one week)
研究者
Prof Herta Flor
Prof. Dr. Herta Flor
Central Institute of Mental Health, Mannheim