Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors and Discovery of Potential Drug Targets
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors
研究概览
简要总结
The goal of this observational study is to compare the immune function and infection mechanism of patients with hematologic tumors and those people without underlying diseases after infection with SARS-CoV-2. Clinical characteristics, treatment options and responses will be collected. Peripheral blood will be collected from patients with hematologic tumors infected with SARS-CoV-2 and those people without underlying diseases infected with SARS-CoV-2.
详细描述
To establish a retrospective and prospective cohort of patients with hematologic tumors infected with SARS-CoV-2 and people without underlying diseases infected with SARS-CoV-2. Firstly, peripheral blood samples will be collected at infection time points and after SARS-CoV-2 nucleic acid testing turns negative. Subsequently, the transcriptome sequencing and immunological experiments will be performed to analyze the differentially expressed genes, immune function of cells, etc.
Comparative analysis:
- To compare the immune function of patients with hematologic tumors and those without underlying diseases after infection with SARS-CoV-2.
- The transcriptomic and proteomic changes of patients with hematologic tumors are compared with those without underlying diseases after infection with SARS-CoV-2.
- From the perspective of complex (human protein interaction subnetwork), the dynamic change process of SARS-CoV-2-targeted human protein complex (periodic complex) was deeply explored, in order to further analyze its potential dynamic infection mechanism and provide new clues for the discovery of drug targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Clinical diagnosis of hematologic tumors Clinical diagnosis of SARS-CoV-2 infection
排除标准
- •- Severe diseases associated with other systems
研究组 & 干预措施
Patients with SARS-CoV-2 positive hematologic tumors
Patients with SARS-CoV-2 positive hematologic tumors over 18 years old excluding patients with severe diseases associated with other systems.
干预措施: None intervention (Other)
People with SARS-CoV-2 positive without underlying diseases
People with SARS-CoV-2 positive without underlying diseases over 18 years old excluding people with severe diseases associated with other systems.
干预措施: None intervention (Other)
结局指标
主要结局
Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors
时间窗: 1 year
To compare the infection mechanism and immune function of patients with hematologic tumors infected with SARS-CoV-2 and people infected with SARS-CoV-2 without underlying diseases.
次要结局
未报告次要终点
研究者
Yujun DONG
chief of department of hematology
Peking University First Hospital