A Randomised, Two-armed, Double-blinded Nutritional Study of Fish Oil on Skin Quality in Healthy Women
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Determine the change in skin quality of healthy women after supplementation with fish oil compared to corn oil
研究概览
简要总结
The skin acts as a barrier against the external environment and prevents water loss from the body. Aging is a natural process leading to changes in the skin and fish oil has been shown to prevent inflammation, hyperpigmentation and UV-damage. This pilot study will determine skin characteristics after intervention with north atlantic fish oil.
详细描述
Women will be recruited to a placebo or fish oil group and be examined at pre- and post for skin quality parameters such as wrinkles, fine lines and trans-epithelial water loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Interventions are given as 1g bovine capsules of equal size, weight and appearance, and provided in identical bottles with a coded label.
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy women in the age of 30-65
- •Able to follow the following dietary restriction for 4 months (4 weeks wash-out, 3 months intervention):
- •Do not take omega-3 supplements
- •do not take supplements containing vitamin A
- •do not take supplements containing collagen
- •try to avoid using skin products containing vitamin A
- •do not undergo skin treatment
排除标准
- •Pregnancy or breast feeding known allergy to seafood skin treatment the last 6 months planned skin treatment during the study period
结局指标
主要结局
Determine the change in skin quality of healthy women after supplementation with fish oil compared to corn oil
时间窗: 3 months
Changes in quantitative analysis of facial inflammation, wrinkles and fine lines and skin texture will be performed using the VISIA Skin Analysis system. Measurements will be made at baseline and at end of supplementation period.
次要结局
- Determine the change in omega-3 index (%EPA and DHA in red blood cells) after daily intake of 4g of north atlantic fish oil compared to placebo(3 months)