Clinical Sequencing Project for Metastatic Cancer Patients for Personalized Cancer Clinic.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Response rate
研究概览
简要总结
The next generation of personalized medical treatment according to the type of personal genetic information are evolving rapidly. The genome analysis needs systematic infra and database based on personal genetic information. Therefore, a big data of genome-clinical information is important.
To determine the feasibility of the use of tumor's molecular profiling and targeted therapies in the treatment of advanced cancer and to determine the clinical outcome(Response rate,PFS, duration of response and overall survival )of patients with advanced cancer, the investigators are going to take a tumor tissue of patients and process molecular profiling and receive molecular profile directed treatments.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject is at least 19 years of age.
- •Subject has a histologically or cytologically confirmed diagnosis of Colorectal cancer.
- •Prior treatment with anti-PDL1 antibody or immune check point inhibitor or ramucirumab therapy in the First-line or maintenance setting is allowed
- •They must have refractory or progressive disease for which there is no further curative therapy available.
- •Be willing to provide fresh tissue for biomarker analysis, and, based on the adequacy of the tissue sample quality for assessment of biomarker status.
- •Must have a life expectancy of 3 months or more
- •Written and voluntary informed consent understood, signed and dated.
排除标准
- •Patients who do not have enough tissue for acquisition
结局指标
主要结局
Response rate
时间窗: 1 year
次要结局
- Progression Free Survival(1 year)
- Duration of response(1 year)
- overall survival(1 year)
研究者
Seung tae Kim
MD,PhD,Division of hematology-oncology,Department of medicine
Samsung Medical Center