Intermittent Preventive Treatment in Infant in Mali

University of Bamako1 site in 1 countryOctober 2006

ConditionsMalaria

DrugsSulfadoxine pyrimethamine

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Malaria
Sponsor: University of Bamako
Locations: 1
Primary Endpoint: EPI vaccines and other health interventions coverage
Status: Completed
Last Updated: 17 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Studies have shown that Intermittent preventive treatment in infants (IPTi) with Sulfadoxine-pyrimethamine (SP)reduced the incidence of clinical malaria and anemia without modifying infants' serological response to EPI vaccines. Thus IPTi was seen as a potential public health tool of great benefit to the children of Africa and a logical addition to the Immunization Plus package. The objectives of this operational researcher were

to develop an implementation model for IPTi in the health care system in Mali
to assess its impact on the EPI vaccines and other health interventions coverage
and on molecular makers of resistance to SP

Detailed Description

The study was implemented in districts of the region of Koulikoro; the district of Koulikoro and the district of Kolokani. The whole district of Koulikoro was covered by the intervention while in Kolokani, the 22 health areas (sub districts) were randomized in 1:1 ratio with the intervention in 11 health areas and the other 11 serving as control for the assessment of the impact of IPTi implementation on EPI vaccines and other health interventions coverage as well as its impact on the resistance to SP. The implementation consisted of administration of ½ tablet of Sulfadoxine -Pyrimethamine with EPI vaccines (DTP2, DTP3 and Measles vaccine) from December 2006 to December 2007.

Registry

clinicaltrials.gov

Start Date

October 2006

End Date

December 2007

Last Updated

17 years ago

Study Type

Interventional

Study Design

Parallel