Phase I Study of the Combination of Temsirolimus (CCI-779) and Pazopanib (GW786034) in Patients With Advanced Solid Tumors
Overview
- Phase
- Phase 1
- Intervention
- Temsirolimus, Pazopanib
- Conditions
- Solid Tumors
- Sponsor
- University of California, Davis
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Feasibility and safety of temsirolimus and pazopanib when given in combination to patients with advanced solid tumors.
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study is to test the safety of temsirolimus and pazopanib at different doses. Patients who have an advanced cancer that is not felt to benefit from standard treatment or are no longer responding to other treatment will be asked to take part in this study. The study hypothesis is that temsirolimus and pazopanib can be administered safely in combination and that combined targeting of the mammalian target of rapamycin (mTOR) and vascular endothelial growth factor receptor (VEGFR) signaling pathways will be effective in treating patients with advanced solid tumors.
Detailed Description
Despite encouraging clinical activity reported with single-agent VEGF inhibitors, mTOR inhibitors, and other novel agents, patients rarely achieve complete disease response and ultimately undergo disease progression. The limited efficacy of single-target inhibition may be due to numerous, overlapping signaling pathways involved in Renal Cell Carcinoma proliferation and growth. A strategy of multi-target "vertical inhibition" of the overlapping aberrant VEGF and mTOR pathways by combination therapy may translate to enhanced efficacy over each single agent alone. We hypothesize that temsirolimus and pazopanib can be administered safely in combination and that combined targeting of the mTOR and VEGFR signaling pathways will be effective in treating patients with advanced solid tumors.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Must have histologically or cytologically confirmed metastatic or unresectable solid tumor for which standard curative or palliative measures do not exist or are no longer effective.
- •Age ≥ 18 years old
- •Zubrod (ECOG) Performance Status 0 - 2
- •May have measurable or non-measurable disease.
- •Adequate bone marrow and organ function as assessed by the following within 14 days prior to registration.
- •Any number of prior chemotherapy regimens is allowed.
- •Any prior chemotherapy, immunotherapy or targeted therapy must have been completed at least 2 weeks prior to start of this protocol and all side effects (except alopecia, lymphopenia and hyperglycemia) resolved to grade 1 or less. Any prior radiation must have been completed at least 2 weeks prior to start of therapy.
- •Pregnant or nursing women are ineligible because of the risk to the fetus. Women of child-bearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
- •Ability to understand and the willingness to sign a written informed consent.
- •Ability to swallow and retain oral medications.
Exclusion Criteria
- •Prior treatment with an mTOR inhibitor or pazopanib.
- •Cardiac disease: Congestive heart failure \> class II NYHA. Patients must not have unstable angina (anginal symptoms at rest) or new onset angina (began within the last 3 months) or myocardial infarction within the past 6 months.
- •Symptomatic or uncontrolled brain metastasis.
- •Must have a EKG within 14 days of registration and a QTc of \< 480 msec. If the initial QTc is \> 480 msec, two subsequent EKGs should be obtained within 5 minutes.
- •Uncontrolled hypertension defined as systolic blood pressure \> 150 mmHg or diastolic pressure \> 90 mmHg, despite optimal medical management.
- •Known human immunodeficiency virus (HIV) infection or chronic Hepatitis B or C due to the immunosuppressive effects of temsirolimus.
- •Active clinically serious infection \> CTCAE Grade
- •Fasting cholesterol \> 350mg/dL and fasting triglycerides \> 400mg/dL
- •Thrombolic or embolic events such as a cerebrovascular accident including transient ischemic attacks within the past 6 months.
- •Pulmonary hemorrhage/bleeding event ≥ CTCAE Grade 2 within 4 weeks of first dose of study drug.
Arms & Interventions
Temsirolimus and Pazopanib
Intervention: Temsirolimus, Pazopanib
Outcomes
Primary Outcomes
Feasibility and safety of temsirolimus and pazopanib when given in combination to patients with advanced solid tumors.
Time Frame: Every 4 weeks (Cycle)
Secondary Outcomes
- Determine the maximum tolerated dose (MTD) of temsirolimus and pazopanib when given in combination to patients with advanced solid tumors and to recommend a phase II dose for the combination.(Every 4 weeks (Cycle))