Effect of vitamin B12 supplementation on anthropometric indices in children with severe acute malnutrition (SAM) aged 1 month to 60 month in a nutritional rehabilitation center - a randomized control trial

Not yet recruiting

Conditions: Unspecified severe protein-caloriemalnutrition,

Registration Number: CTRI/2023/09/057950

Lead Sponsor: Moti Lal Nehru Medical College Allahabad

Brief Summary: Vitamin B12 defficiency is commonly associated in children with severe acute malnutrition and is not used as routine supplements according to WHO guidelines of management of severe acute malnutrition in facility.Vitamin B12 and folate deficiency leads to megaloblastic anemia, poor growth and increased infections.We aim to look for the effect of vitamin B12 supplementation of anthropometric indices and improvement of anemia in children with severe acute malnutrition

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 180

Inclusion Criteria

1.Parents or guardians willing to give written informed consent 2.Age group of 1 month to 60 month children with severe acute malnutrition(SAM) 3.SAM will be defined as : Mid upper arm circumference (MUAC) <11.5 cm and/or weight for height/length <-3 standard deviation and/or bilateral pitting edema.

Exclusion Criteria

All children with non-nutritional anaemia (malignancy,haemolytic anaemia and aplastic anaemia) 2.
Children diagnosed to have chronic liver disease, chronic kidney disease, GIT disorder(inflammatory bowel disorders),heart disease,infantile tremor syndrome 3.
Children with unstable viatals.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
change in anthropometric parameters ( weight and height) after vitamin B12 supplementation	1 year

Secondary Outcome Measures

Name	Time	Method
1.Document changes in Hb levels and MCV levels	2.Describe the prevalence of anemia in enrolled patients

Trial Locations

Locations (1): Moti Lal Nehru Medical College, Allahabad
🇮🇳
Allahabad, UTTAR PRADESH, India
Moti Lal Nehru Medical College, Allahabad
🇮🇳Allahabad, UTTAR PRADESH, India
Dr Bhartendu Krishna Pathak
Principal investigator
7905674638
bkpathak06@gmail.com