Neurocognitive Development in Children Who Received General Anesthesia Before the Age of 3 Years: A Historic-prospective, Controlled, Single Center Cross-section Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- University of Erlangen-Nürnberg Medical School
- Enrollment
- 700
- Locations
- 1
- Primary Endpoint
- Cognitive Capacity for children between 7 and 10 years of age
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The infantile brain has to pass essential, mayor steps in the first 36 months of life. During that period of development it is particularly vulnerable to toxic, exogenic influences. This study wants to review the long-term effects of children who were exposed to anesthesia in the first three years of their life. Therefore the investigators will examine children at age of 4-10 that were exposed to anesthesia and compare their neurocognitive capacity to children who did not have any exposure to anesthesia. The investigators plan on measuring the intelligence quotient using standardized tests which will be performed by a trained psychologist. In addition there will be a questionnaire concerning behavioral characteristics and educational development which is filled by the parents. The exposed children will be recruited from our preexisting database, the control group will be recruited from practitioners and the pediatric walk-in-clinic.
Investigators
Tino Münster
Prof. Dr.
University of Erlangen-Nürnberg Medical School
Eligibility Criteria
Inclusion Criteria
- •General anesthesia before the age of 36 months
Exclusion Criteria
- •neurosurgical interventions
- •cardiac surgery
- •preexisting hereditary or acquired cognitive deficits
- •no informed consent
Outcomes
Primary Outcomes
Cognitive Capacity for children between 7 and 10 years of age
Time Frame: Test is done 1 to 10 years after anesthesia and is lasting 3 hours
Standardized tests for intelligence quotient (IQ): Kaufman Assessment Battery for Children - Second Edition (KABC-II)
Cognitive Capacity for children between 2 and 4 years of age
Time Frame: Test is done 1 to 10 years after anesthesia and is lasting 3 hours
Standardized tests for intelligence quotient (IQ): Wechsler Intelligence Scale for Children (WISC-IV)
Cognitive Capacity for children between 4 and 7 years of age
Time Frame: Test is done 1 to 10 years after anesthesia and is lasting 3 hours
Standardized tests for intelligence quotient (IQ): Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III)
Secondary Outcomes
- Educational status(1 to 10 years after anesthesia, lasting 30 minutes)