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临床试验/NCT05212506
NCT05212506Unknown不适用

Association of Seminal Plasma SARS-Cov19 IgG Level With Semen Parameters and Embryological Characteristics in Vaccinated Normozoospermic Men

Shanghai First Maternity and Infant Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2022年1月最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
试验地点
1
主要终点
semen index

研究概览

简要总结

Since December 2019, more and more cases of unexplained pneumonia appeared after exposure to the South China Seafood Market in Wuhan City, Hubei Province. Later, the disease were confirmed to be acute respiratory infectious diseases caused by the 2019 new coronavirus infection.

Even though we have had great victories in the war against this pandemic, there is still a very large number of deaths early on. As research progresses, vaccines for this infectious disease are already being developed. There are currently two vaccines in widespread use worldwide: mRNA vaccines and inactivated vaccines. In China, inactivated vaccines are more commonly used. At present, some studies believe that mRNA vaccine does not affect the pregnancy rate and abortion rate of women, but the study sample size is small, and the conclusions are limited. The effects of inactivated vaccines on fertility are still in the blank. We now hope to conduct prospective studies, mainly to study the effect of inactivated vaccine injection on male semen, and whether it has an effect on the quality of embryos in IVF patients

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
22 Years 至 50 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • The man's semen quality is normal,
  • The couple meets the indications for IVF,
  • injected with the covid-19 vaccine

排除标准

  • In vitro fertilization due to male factors
  • Azoospermia
  • The quality of the man's semen is abnormal

结局指标

主要结局

semen index

时间窗: 2022.01-2022.03

the semen index of the participants

次要结局

  • embryo quality(2022.02-2022.05)
  • clinical pregnant rate(2022.03-2022.05)
  • Fertilization rate(2022.01-2022.04)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

chen zhi qin

doctor

Shanghai First Maternity and Infant Hospital

研究点 (1)

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