Association of Seminal Plasma SARS-Cov19 IgG Level With Semen Parameters and Embryological Characteristics in Vaccinated Normozoospermic Men
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- semen index
Study Overview
Brief Summary
Since December 2019, more and more cases of unexplained pneumonia appeared after exposure to the South China Seafood Market in Wuhan City, Hubei Province. Later, the disease were confirmed to be acute respiratory infectious diseases caused by the 2019 new coronavirus infection.
Even though we have had great victories in the war against this pandemic, there is still a very large number of deaths early on. As research progresses, vaccines for this infectious disease are already being developed. There are currently two vaccines in widespread use worldwide: mRNA vaccines and inactivated vaccines. In China, inactivated vaccines are more commonly used. At present, some studies believe that mRNA vaccine does not affect the pregnancy rate and abortion rate of women, but the study sample size is small, and the conclusions are limited. The effects of inactivated vaccines on fertility are still in the blank. We now hope to conduct prospective studies, mainly to study the effect of inactivated vaccine injection on male semen, and whether it has an effect on the quality of embryos in IVF patients
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 22 Years to 50 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •The man's semen quality is normal,
- •The couple meets the indications for IVF,
- •injected with the covid-19 vaccine
Exclusion Criteria
- •In vitro fertilization due to male factors
- •Azoospermia
- •The quality of the man's semen is abnormal
Outcomes
Primary Outcomes
semen index
Time Frame: 2022.01-2022.03
the semen index of the participants
Secondary Outcomes
- embryo quality(2022.02-2022.05)
- clinical pregnant rate(2022.03-2022.05)
- Fertilization rate(2022.01-2022.04)
Investigators
chen zhi qin
doctor
Shanghai First Maternity and Infant Hospital
